Resumen
(Chemical Equation Presented) An unusual Michael addition between 2-aryl-substituted acrylates and 3,3-dimethoxypropanenitrile which leads, depending on the reaction temperature (60 or -78 °C, respectively), to a 4-methoxymethylene-substituted 4-cyanobutyric ester or to a 4-dimethoxymethyl 4-cyanobutyric ester is described. These compounds can be subsequently converted to 4-unsubstituted pyrido[2,3-d]-pyrimidines upon treatment with a guanidine system under microwave irradiation.
Idioma original | Inglés |
---|---|
Páginas (desde-hasta) | 487-490 |
Número de páginas | 4 |
Publicación | Journal of Organic Chemistry |
Volumen | 75 |
N.º | 2 |
DOI | |
Estado | Publicada - 15 ene 2010 |