Alterations in topology, cost, and dynamics of gamma-band EEG functional networks in a preclinical model of traumatic brain injury

Traumatic brain injury (TBI) is a prevalent neurological disorder caused by factors such as accidents, contact sports, or military conflict. While animal studies have provided detailed insights into the molecular and cellular mechanisms underlying TBI, and clinical research has revealed its effects on large-scale brain network organization, these findings often lack integration. Our research seeks to address this gap by examining large-scale brain activity in an animal model of TBI. By analyzing brain network structures, we identify reorganization, highlighting novel connections to weight gain and posttraumatic epilepsy. Further exploration using this model may deepen our understanding of cross-scale mechanisms and inform the development of therapeutic interventions.