A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

Oriol Planas; Thibault Gallavardin; Santi Nonell

doi:10.1039/c4cc09070e

A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

Oriol Planas, Thibault Gallavardin, Santi Nonell

Producción científica: Artículo en revista indizada › Artículo › revisión exhaustiva

32 Citas (Web of Science)

Resumen

Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.

Idioma original	Inglés
Páginas (desde-hasta)	5586-5589
Número de páginas	4
Publicación	Chemical Communications
Volumen	51
N.º	26
DOI	https://doi.org/10.1039/c4cc09070e
Estado	Publicada - 4 abr 2015

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abstract = "Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.",

keywords = "Photodynamic therapy, Photophysical properties, Probe-design, Live-cell, Porphycene, Fluorescence, 2-aminobenzothiazoles, Photosensitizer, Derivatives, Cancer",

author = "Oriol Planas and Thibault Gallavardin and Santi Nonell",

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doi = "10.1039/c4cc09070e",

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AU - Planas, Oriol

AU - Gallavardin, Thibault

AU - Nonell, Santi

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015/4/4

Y1 - 2015/4/4

N2 - Reaction of porphycene isothiocyanates with primary and secondary amines leads to the formation of thiazolo[4,5-c]porphycenes, with a substantial shift in the absorption and fluorescence spectra. The conjugates show fluorescence in the near-infrared and are capable of photosensitizing the production of the cytotoxic species singlet oxygen.

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KW - Photodynamic therapy

KW - Photophysical properties

KW - Probe-design

KW - Live-cell

KW - Porphycene

KW - Fluorescence

KW - 2-aminobenzothiazoles

KW - Photosensitizer

KW - Derivatives

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JO - Chemical Communications

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A novel fluoro-chromogenic click reaction for the labelling of proteins and nanoparticles with near-IR theranostic agents

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