A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

Rubén Ruiz-González; John H. White; Montserrat Agut; Santi Nonell; Cristina Flors

doi:10.1039/c2pp25126d

A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

Rubén Ruiz-González, John H. White, Montserrat Agut, Santi Nonell^*, Cristina Flors

^*Autor/a de correspondencia de este trabajo

Producción científica: Artículo en revista indizada › Artículo › revisión exhaustiva

23 Citas (Scopus)

Resumen

TagRFP, a fluorescent protein capable of photosensitizing the production of singlet oxygen, was expressed in E. coli. Subsequent exposure to green light induced bacterial cell death in a light-dose dependent manner. It is demonstrated for the first time that intracellular singlet oxygen is sufficient to kill bacteria.

Idioma original	Inglés
Páginas (desde-hasta)	1411-1413
Número de páginas	3
Publicación	Photochemical and Photobiological Sciences
Volumen	11
N.º	9
DOI	https://doi.org/10.1039/c2pp25126d
Estado	Publicada - sept 2012

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title = "A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen",

abstract = "TagRFP, a fluorescent protein capable of photosensitizing the production of singlet oxygen, was expressed in E. coli. Subsequent exposure to green light induced bacterial cell death in a light-dose dependent manner. It is demonstrated for the first time that intracellular singlet oxygen is sufficient to kill bacteria.",

keywords = "Photodynamic therapy, Escherichia-coli, Inactivation, Light",

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AU - Ruiz-González, Rubén

AU - White, John H.

AU - Agut, Montserrat

AU - Nonell, Santi

AU - Flors, Cristina

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KW - Photodynamic therapy

KW - Escherichia-coli

KW - Inactivation

KW - Light

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A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

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