A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress

Jordi Martorell López; Mercedes Balcells Camps; Gemma Molins Gutiérrez; Antonio Gabino Salazar Gabino

doi:10.1007/978-1-0716-2289-6_10

A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress

Título traducido de la contribución: A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress

Producción científica: Capítulo del libro › Capítulo

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The blood–brain barrier (BBB) consists of a tight network of blood capillaries in the brain that separate the circulatory system from the central nervous system. Its particular properties are based on the dynamic interaction between cerebral endothelial cells and other surrounding cells, especially astrocytes. We have designed and synthesized a three-dimensional scaffold that recapitulates the main hallmarks of the BBB extracellular matrix and serves as a platform to co-culture human brain microvascular endothelial cells and human cortical astrocytes. The scaffold can be exposed to flow, thereby allowing the study of flow-mediated pathways at the BBB.

Título traducido de la contribución	A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress
Idioma original	Inglés
Título de la publicación alojada	The Blood-Brain Barrier
Editorial	Springer Nature
Páginas	175-190
Número de páginas	0
Volumen	2492
ISBN (versión impresa)	978-1-0716-2289-6
DOI	https://doi.org/10.1007/978-1-0716-2289-6_10
Estado	Publicada - 1 jun 2022

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abstract = "The blood–brain barrier (BBB) consists of a tight network of blood capillaries in the brain that separate the circulatory system from the central nervous system. Its particular properties are based on the dynamic interaction between cerebral endothelial cells and other surrounding cells, especially astrocytes. We have designed and synthesized a three-dimensional scaffold that recapitulates the main hallmarks of the BBB extracellular matrix and serves as a platform to co-culture human brain microvascular endothelial cells and human cortical astrocytes. The scaffold can be exposed to flow, thereby allowing the study of flow-mediated pathways at the BBB.",

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note = "This work was supported in part by a grant from Spain Ministerio de Econom{\'i}a y Competitividad (SAF-2017-84773-C2, MB) and by the Global CoCreation Lab (GM, MB).",

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AU - Balcells Camps, Mercedes

AU - Molins Gutiérrez, Gemma

AU - Salazar Gabino, Antonio Gabino

N1 - This work was supported in part by a grant from Spain Ministerio de Economía y Competitividad (SAF-2017-84773-C2, MB) and by the Global CoCreation Lab (GM, MB).

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A Dynamic, in vitro BBB model to study the effects of varying levels of shear stress

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