Resumen
The synthesis of dimethyl 2-(methoxymethylene) pentanedioates by an unusual Michael addition of 3,3-dimethoxypropionate to α, β-unsaturated esters is described. These new intermediates can subsequently be converted to methyl 3-(2-amino-1,6-dihydro-6-oxo-pyrimidin-5-yl)propanoates upon treatment with guanidine carbonate. The resulting pyrimidine derivatives are open-chain analogues of pyrido[2,3-d]pyrimidines with interesting biological activities.
Idioma original | Inglés |
---|---|
Páginas (desde-hasta) | 595-601 |
Número de páginas | 7 |
Publicación | Molecular Diversity |
Volumen | 15 |
N.º | 2 |
DOI | |
Estado | Publicada - may 2011 |