A convenient synthesis of 13N-labelled azo compounds: A new route for the preparation of amyloid imaging PET probes

Vanessa Gómez-Vallejo, José I. Borrell, Jordi Llop

Producción científica: Artículo en revista indizadaArtículorevisión exhaustiva

18 Citas (Scopus)

Resumen

In the present paper, a fast and automated method for the synthesis of 13N-labelled azo compounds is reported for the first time. The labelling strategy is based on trapping [13N]NO2 - in an anion exchange resin. The reaction with primary aromatic amines in acidic media led to the formation of the corresponding diazonium salts, which were further reacted with aromatic amines and alcohols to yield the corresponding 13N-labelled azo derivatives with good radiochemical conversion (40.0-58.3%). Good radiochemical yields (20.4-47.2%, decay corrected) and radiochemical purities (>99.9%) were obtained after purification by HPLC. Such methodology can be easily applied to the preparation of a wide range of 13N-labelled azo derivatives by adequate selection of the non-radioactive precursors.

Idioma originalInglés
Páginas (desde-hasta)5318-5323
Número de páginas6
PublicaciónEuropean Journal of Medicinal Chemistry
Volumen45
N.º11
DOI
EstadoPublicada - nov 2010

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