A comparative study on two cationic porphycenes: Photophysical and antimicrobial photoinactivation evaluation

Rubén Ruiz-González, Montserrat Agut, Elena Reddi, Santi Nonell

Producción científica: Artículo en revista indizadaArtículorevisión exhaustiva

23 Citas (Scopus)

Resumen

Over the last decades, the number of pathogenic multi-resistant microorganisms has grown dramatically, which has stimulated the search for novel strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT) is one of the promising alternatives to conventional treatments based on antibiotics. Here, we present a comparative study of two aryl tricationic porphycenes where photoinactivation efficiency against model pathogenic microorganisms is correlated to the photophysical behavior of the porphycene derivatives. Moreover, the extent of photosensitizer cell binding to bacteria has been assessed by flow cytometry in experiments with, or without, removing the unbound porphycene from the incubation medium. Results show that the peripheral substituent change do not significantly affect the overall behavior for both tricationic compounds neither in terms of photokilling efficiency, nor in terms of binding.

Idioma originalInglés
Páginas (desde-hasta)27072-27086
Número de páginas15
PublicaciónInternational Journal of Molecular Sciences
Volumen16
N.º11
DOI
EstadoPublicada - 12 nov 2015

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