TY - JOUR
T1 - 4-Amino-2-arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3- d ]pyrimidin-7-(8 H)-ones as BCR kinase inhibitors for B lymphoid malignancies
AU - Puig De La Bellacasa, Raimon
AU - Roué, Gaël
AU - Balsas, Patricia
AU - Pérez-Galán, Patricia
AU - Teixidó, Jordi
AU - Colomer, Dolors
AU - Borrell, José I.
N1 - Funding Information:
The authors appreciate the financial support from the Spanish Ministerio de Economía y Competitividad projects SAF2010-C21617-C02 (J.I.B.), SAF 09/9503 and SAF 12/31242 (D.C.), SAF 11/29326 (P.P.-G.), Redes Temáticas de Investigación Cooperativa de Cáncer from the Instituto de Salud Carlos III ( RD2006/20/014 and RD12/0036/0004 ) and Generalitat de Catalunya 2009SGR967 (D.C.), Fondo de Investigación Sanitaria, European Regional Development Fund (ERDF) “Una manera de hacer Europa” grants PI09/0060 and PI12/01847 (G.R.). R. Puig de la Bellacasa wants to thank Generalitat de Catalunya for a grant within the Talent empresa (TEM) 2009 program (2009 TEM 00128).
Publisher Copyright:
© 2014 Elsevier Masson SAS. All rights reserved.
PY - 2014/10/30
Y1 - 2014/10/30
N2 - A new family of 4-aminopyrido[2,3-d]pyrimidines active against non-Hodgkin's lymphomas (NHLs) is described. Among these compounds, 19 inhibits the most upstream tyrosine kinases in the B cell receptor (BCR) signaling pathway which are involved in the mature B cell neoplasms. Thus, 19 showed antiproliferative activity at 24 h and 48 h against a panel of 20 NHLs cell lines with GI50 ranging from 1.3 to 6.9 Î.
AB - A new family of 4-aminopyrido[2,3-d]pyrimidines active against non-Hodgkin's lymphomas (NHLs) is described. Among these compounds, 19 inhibits the most upstream tyrosine kinases in the B cell receptor (BCR) signaling pathway which are involved in the mature B cell neoplasms. Thus, 19 showed antiproliferative activity at 24 h and 48 h against a panel of 20 NHLs cell lines with GI50 ranging from 1.3 to 6.9 Î.
KW - 7-oxopyrido[2,3-d]pyrimidines
KW - B-cell receptor
KW - Kinases
KW - Non-Hodgkin's lymphomas
KW - Small molecule inhibitor
UR - https://www.scopus.com/pages/publications/84907815262
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=pure_univeritat_ramon_llull&SrcAuth=WosAPI&KeyUT=WOS:000343781800059&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/j.ejmech.2014.09.018
DO - 10.1016/j.ejmech.2014.09.018
M3 - Article
C2 - 25222877
AN - SCOPUS:84907815262
SN - 0223-5234
VL - 86
SP - 664
EP - 675
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
ER -