Ultraearly hematoma growth in active intracerebral hemorrhage

David Rodriguez-Luna, Pilar Coscojuela, Marta Rubiera, Michael D. Hill, Dar Dowlatshahi, Richard I. Aviv, Yolanda Silva, Imanuel Dzialowski, Cheemun Lum, Anna Czlonkowska, Jean Martin Boulanger, Carlos S. Kase, Gord Gubitz, Rohit Bhatia, Vasantha Padma, Jayanta Roy, Alejandro Tomasello, Andrew M. Demchuk, Carlos A. Molina

Research output: Indexed journal article Articlepeer-review

54 Citations (Scopus)


Objective: To determine the association of ultraearly hematoma growth (uHG) with the CT angiography (CTA) spot sign, hematoma expansion, and clinical outcomes in patients with acute intracerebral hemorrhage (ICH). Methods: We analyzed data from 231 patients enrolled in the multicenter Predicting Haematoma Growth and Outcome in Intracerebral Haemorrhage Using Contrast Bolus CT study. uHG was defined as baseline ICH volume/onset-to-CT time (mL/h). The spot sign was used as marker of active hemorrhage. Outcome parameters included significant hematoma expansion (>33% or >6 mL, primary outcome), rate of hematoma expansion, early neurologic deterioration, 90-day mortality, and poor outcome. Results: uHG was higher in spot sign patients (p < 0.001) and in patients scanned earlier (p < 0.001). Both uHG >4.7 mL/h (p 0.002) and the CTA spot sign (p 0.030) showed effects on rate of hematoma expansion but not its interaction (2-way analysis of variance, p 0.477). uHG >4.7 mL/h improved the sensitivity of the spot sign in the prediction of significant hematoma expansion (73.9% vs 46.4%), early neurologic deterioration (67.6% vs 35.3%), 90-day mortality (81.6% vs 44.9%), and poor outcome (72.8% vs 29.8%), respectively. uHG was independently related to significant hematoma expansion (odds ratio 1.06, 95% confidence interval 1.03-1.10) and clinical outcomes. Conclusions: uHG is a useful predictor of hematoma expansion and poor clinical outcomes in patients with acute ICH. The combination of high uHG and the spot sign is associated with a higher rate of hematoma expansion, highlighting the need for very fast treatment in ICH patients.

Original languageEnglish
Pages (from-to)357-364
Number of pages8
Issue number4
Publication statusPublished - 26 Jul 2016
Externally publishedYes


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