Ubiquitin and SUMO signalling in DNA repair

Timothy M. Thomson, Marta Guerra-Rebollo

Research output: Indexed journal article Reviewpeer-review

29 Citations (Scopus)


The repair of lesions and gaps in DNA follows different pathways, each mediated by specific proteins and complexes. Post-translational modifications in many of these proteins govern their activities and interactions, ultimately determining whether a particular pathway is followed. Prominent among these modifications are the addition of phosphate or ubiquitin (and ubiquitin-like) moieties that confer new binding surfaces and conformational states on the modified proteins. The present review summarizes some of consequences of ubiquitin and ubiquitin-like modifications and interactions that regulate nucleotide excision repair, translesion synthesis, double-strand break repair and interstrand cross-link repair, with the discussion of relevant examples in each pathway.

Original languageEnglish
Pages (from-to)116-131
Number of pages16
JournalBiochemical Society Transactions
Issue number1
Publication statusPublished - 2010
Externally publishedYes


  • DNA damage
  • DNA repair
  • Phosphorylation
  • Small ubiquitin-related modifier (SUMO)
  • Ubiquitin


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