Two-component systems of Mycobacterium tuberculosis as potential targets for drug development

Marta Marszalek; Antoni Planas; Teresa Pellicer

Two-component systems of Mycobacterium tuberculosis as potential targets for drug development

Marta Marszalek
, Antoni Planas^*
, Teresa Pellicer

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

4 Citations (Scopus)

Abstract

many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.

Original language	English
Pages (from-to)	172-178
Number of pages	7
Journal	Afinidad
Volume	71
Issue number	567
Publication status	Published - 1 Jul 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Drug targets
Latency
Tuberculosis
Two-component system

Cite this

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abstract = "many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.",

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N2 - many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.

AB - many different environmental conditions therefore are considered potential pharmacological targets for the development of novel antimycobacterial drugs. In this work, we review the current knowledge of the TCSs of Mycobacterium tuberculosis. We discuss their role in bacterial pathogenesis and virulence. We pay special attention to the DosS/DosT/DosR TCS, emphasizing its importance in latent tuberculosis development.

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KW - Latency

KW - Tuberculosis

KW - Two-component system

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ER -

Two-component systems of Mycobacterium tuberculosis as potential targets for drug development

Abstract

UN SDGs

Keywords

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