@article{e494c71a63164376b1e3f65222b4b565,
title = "Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo",
abstract = "In this paper we establish a methodology to predict photoacoustic imaging capabilities from the structure of absorber molecules (sonochromes). The comparative in vitro and in vivo screening of naphthalocyanines and cyanine dyes has shown a substitution pattern dependent shift in photoacoustic excitation wavelength, with distal substitution producing the preferred maximum around 800 nm. Central ion change showed variable production of photoacoustic signals, as well as singlet oxygen photoproduction and fluorescence with the optimum for photoacoustic imaging being nickel(II). Our approach paves the way for the design, evaluation and realization of optimized sonochromes as photoacoustic contrast agents.",
keywords = "Naphthalocyanines, Spectroscopy",
author = "Duffy, {Mitchell J.} and Oriol Planas and Andreas Faust and Thomas Vogl and Sven Hermann and Michael Sch{\"a}fers and Santi Nonell and Strassert, {Cristian A.}",
note = "Funding Information: Additional financial support for this research was obtained from the Spanish Ministerio de Econom{\'i}a y Competitividad (grant nos. CTQ2013-48767-C3-1-R , CTQ2016-78454-C2-1-R and CTQ2015-71896-REDT ). Oriol Planas thanks the European Social Funds and the SUR del DEC de la Generalitat de Catalunya for his predoctoral fellowship (grant no. 2016 FI_B2_00100). Funding Information: This work was supported by a fellowship of the Graduate School of the Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University of M{\"u}nster, Germany to Mitchell Duffy. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
month = mar,
doi = "10.1016/j.pacs.2017.12.001",
language = "English",
volume = "9",
pages = "49--61",
journal = "Photoacoustics",
issn = "2213-5979",
publisher = "Elsevier GmbH",
}