Temocene: the porphycene analogue of temoporfin (Foscan®)

María García-Díaz; David Sánchez-García; Jorge Soriano; M. Lluïsa Sagristà; Margarita Mora; Ángeles Villanueva; Juan C. Stockert; Magdalena Cañete; Santi Nonell

doi:10.1039/c1md00065a

Temocene: the porphycene analogue of temoporfin (Foscan®)

María García-Díaz
, David Sánchez-García
, Jorge Soriano
, M. Lluïsa Sagristà
, Margarita Mora
, Ángeles Villanueva
, Juan C. Stockert
, Magdalena Cañete
, Santi Nonell^*

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

36 Citations (Scopus)

Abstract

Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.

Original language	English
Pages (from-to)	616-619
Number of pages	4
Journal	MedChemComm
Volume	2
Issue number	7
DOIs	https://doi.org/10.1039/c1md00065a
Publication status	Published - Jul 2011

Keywords

Photodynamic therapy
Photosensitizers
Tetraphenylporphycene
Apoptosis
Porphyrin

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10.1039/c1md00065a

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abstract = "Temocene, a porphycene analogue of temoporfin, has been synthesized. Compared to temoporfin, temocene is endowed with 2.5-fold larger absorption coefficients in the red part of the spectrum while keeping its excellent photophysical and singlet oxygen photosensitization ability. While its photodynamic activity towards HeLa cells is lower than that of temoporfin, its higher photostability, lower dark toxicity and mitochondrial localisation make temocene a promising candidate for photodynamic therapy applications.",

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T2 - the porphycene analogue of temoporfin (Foscan®)

AU - García-Díaz, María

AU - Sánchez-García, David

AU - Soriano, Jorge

AU - Sagristà, M. Lluïsa

AU - Mora, Margarita

AU - Villanueva, Ángeles

AU - Stockert, Juan C.

AU - Cañete, Magdalena

AU - Nonell, Santi

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KW - Tetraphenylporphycene

KW - Apoptosis

KW - Porphyrin

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Temocene: the porphycene analogue of temoporfin (Foscan®)

Abstract

Keywords

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