Abstract
We report on the synthesis of 2,7,12,17-tetraphenylporphycene (TPPo), the first example of an aryl-substituted porphycene macrocycle. A modification of the general porphycene synthetic method has been used, thus avoiding an intermediate sublimation. TPPo has an absorption maximum at 659 nm (ε = 50.000 M-1cm-1), and shows good sensitizing properties: it photoproduces singlet oxygen with a quantum yield of ca. 0.25, is phototoxic to cells, and has low dark toxicity. These properties make TPPo a suitable candidate for the photodynamic therapy of tumors.
Original language | English |
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Pages (from-to) | 3405-3408 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 36 |
Issue number | 19 |
DOIs | |
Publication status | Published - 8 May 1995 |