Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery

Pan Kaj Garg; Shambhavi Pandey; Hong Nam Kim; Hoon Seonwoo; Sunho Park; Kyoung Soon Choi; Kyoung Je Jang; Hoon Hyun; Phil Hoon Choung; Jangho Kim; Jong Hoon Chung

doi:10.1039/c6ra09348e

Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery

Pan Kaj Garg, Shambhavi Pandey, Hong Nam Kim, Hoon Seonwoo, Sunho Park, Kyoung Soon Choi, Kyoung Je Jang, Hoon Hyun, Phil Hoon Choung, Jangho Kim, Jong Hoon Chung

Research output: Indexed journal article › Article › peer-review

3 Citations (Scopus)

Abstract

Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic cues in designing non-viral gene delivery platforms and strategies for gene therapy.

Original language	English
Pages (from-to)	111233-111238
Number of pages	6
Journal	RSC Advances
Volume	6
Issue number	112
DOIs	https://doi.org/10.1039/c6ra09348e
Publication status	Published - 2016
Externally published	Yes

Keywords

Mesenchymal stem-cells
Endocytosis
Differentiation
Transfection
Stiffness
Systems
Matrix
Sirna

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10.1039/c6ra09348e

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title = "Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery",

abstract = "Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic cues in designing non-viral gene delivery platforms and strategies for gene therapy.",

keywords = "Mesenchymal stem-cells, Endocytosis, Differentiation, Transfection, Stiffness, Systems, Matrix, Sirna",

author = "Garg, {Pan Kaj} and Shambhavi Pandey and Kim, {Hong Nam} and Hoon Seonwoo and Sunho Park and Choi, {Kyoung Soon} and Jang, {Kyoung Je} and Hoon Hyun and Choung, {Phil Hoon} and Jangho Kim and Chung, {Jong Hoon}",

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AU - Garg, Pan Kaj

AU - Pandey, Shambhavi

AU - Kim, Hong Nam

AU - Seonwoo, Hoon

AU - Park, Sunho

AU - Choi, Kyoung Soon

AU - Jang, Kyoung Je

AU - Hyun, Hoon

AU - Choung, Phil Hoon

AU - Kim, Jangho

AU - Chung, Jong Hoon

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

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AB - Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic cues in designing non-viral gene delivery platforms and strategies for gene therapy.

KW - Mesenchymal stem-cells

KW - Endocytosis

KW - Differentiation

KW - Transfection

KW - Stiffness

KW - Systems

KW - Matrix

KW - Sirna

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Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery

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Keywords

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