Spatial Control of Neuronal Adhesion on Diamond-Like Carbon

James M. Dugan, Carles Colominas, Andrés Amador Garcia-Granada, Frederik Claeyssens

Research output: Indexed journal article Articlepeer-review

1 Citation (Scopus)

Abstract

This study reports a route to spatial control of neuronal adhesion onto Diamond-Like Carbon (DLC) by surface functionalisation by poly (oligo-ethyleneglycol methacrylate) (pOEGMA) and consequent laser ablation to produce cell adhesive tracks. DLC can be deposited as a tough and low friction coating on implantable devices and surgical instruments and has favourable properties for use as a biomaterial. The pOEGMA surface coating renders the DLC surface antifouling and the laser ablation creates graphitised tracks on the surface. The surfaces were coated with laminin, which adhered preferentially to the ablation tracks. The patterned surfaces were investigated for neuronal cell growth with NG108-15 cells for short term culture and rat neural stem cells for longer term culture. The cells initially adhered highly selectively to the ablation tracks while longer term cell culture revealed a more uniform cell coverage of the surface.

Original languageEnglish
Article number756055
JournalFrontiers in Materials
Volume8
DOIs
Publication statusPublished - 22 Nov 2021

Keywords

  • atom transfer radical polymerization
  • diamond-like carbon
  • laser ablation
  • neuronal cell culture
  • poly(oligo (ethylene glycol) methacrylate)

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