Abstract
A modular and practical synthesis of highly substituted oxazoles has been developed. The transformation consists of a sequential copper-catalyzed amidation of vinyl halides followed by cyclization promoted by iodine. A wide variety of functionalized oxazoles and polyazoles can be obtained in a selective manner from simple and easily accessible precursors.
Original language | English |
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Pages (from-to) | 5521-5524 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 9 |
Issue number | 26 |
DOIs | |
Publication status | Published - 20 Dec 2007 |
Externally published | Yes |