Sequential copper-catalyzed vinylation/ cyclization: An efficient synthesis of functionalized oxazoles

Rubén Martín, Ana Cuenca, Stephen L. Buchwald

Research output: Indexed journal article Articlepeer-review

137 Citations (Scopus)

Abstract

A modular and practical synthesis of highly substituted oxazoles has been developed. The transformation consists of a sequential copper-catalyzed amidation of vinyl halides followed by cyclization promoted by iodine. A wide variety of functionalized oxazoles and polyazoles can be obtained in a selective manner from simple and easily accessible precursors.

Original languageEnglish
Pages (from-to)5521-5524
Number of pages4
JournalOrganic Letters
Volume9
Issue number26
DOIs
Publication statusPublished - 20 Dec 2007
Externally publishedYes

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