TY - JOUR
T1 - Role of Siglecs in viral infections
T2 - A double-edged sword interaction
AU - Raïch-Regué, Dàlia
AU - Resa-Infante, Patricia
AU - Gallemí, Marçal
AU - Laguia, Fernando
AU - Muñiz-Trabudua, Xabier
AU - Muñoz-Basagoiti, Jordana
AU - Perez-Zsolt, Daniel
AU - Chojnacki, Jakub
AU - Benet, Susana
AU - Clotet, Bonaventura
AU - Martinez-Picado, Javier
AU - Izquierdo-Useros, Nuria
N1 - Funding Information:
NI-U is supported by the Spanish Ministry of Science and Innovation (grant PID2020-117145RB-I00 , Spain), EU HORIZON-HLTH-2021-CORONA-01 (grant 101046118 , European Union) and by institutional funding of Grifols, Pharma Mar , HIPRA , Amassence and Palobiofarma (Spain). Research in the JM-P lab is supported by the Spanish Ministry of Science and Innovation (grants PID2019-109870RB-I00 and CB21/13/00063 , Spain), NIH/NIAID ( 1 UM1 AI164561-01 , United States of America), EU HORIZON-HLTH-2021-DISEASE-04-07 (grant 101057100, European Union), Research Centers of Catalonia (CERCA, grant 2017 SGR 252 , Spain), Fundació La Marató de TV3 (grant 202130-30-31-32 , Spain), Generalitat de València (grant PROMETEO/2021/036 , Spain), and Grifols (Spain). XM-T is supported by the Spanish Ministry of Science, Innovation and Universities and the European Regional Development Fund under agreement No. BES-2017-082900 (Spain). FL-N is supported by the Spanish Ministry of Science and Innovation and the European Social Fund under agreement No. PRE-2020-095004 (Spain).
Publisher Copyright:
© 2022 The Authors
PY - 2023/4
Y1 - 2023/4
N2 - Sialic-acid-binding immunoglobulin-like lectins are cell surface immune receptors known as Siglecs that play a paramount role as modulators of immunity. In recent years, research has underscored how the underlaying biology of this family of receptors influences the outcome of viral infections. While Siglecs are needed to promote effective antiviral immune responses, they can also pave the way to viral dissemination within tissues. Here, we review how recent preclinical findings focusing on the interplay between Siglecs and viruses may translate into promising broad-spectrum therapeutic interventions or key biomarkers to monitor the course of viral infections.
AB - Sialic-acid-binding immunoglobulin-like lectins are cell surface immune receptors known as Siglecs that play a paramount role as modulators of immunity. In recent years, research has underscored how the underlaying biology of this family of receptors influences the outcome of viral infections. While Siglecs are needed to promote effective antiviral immune responses, they can also pave the way to viral dissemination within tissues. Here, we review how recent preclinical findings focusing on the interplay between Siglecs and viruses may translate into promising broad-spectrum therapeutic interventions or key biomarkers to monitor the course of viral infections.
KW - Antiviral
KW - Ebola virus
KW - HIV-1
KW - SARS-CoV-2
KW - Siglecs
KW - Hiv-1
UR - https://www.scopus.com/pages/publications/85136047157
U2 - 10.1016/j.mam.2022.101113
DO - 10.1016/j.mam.2022.101113
M3 - Review
C2 - 35981912
AN - SCOPUS:85136047157
SN - 0098-2997
VL - 90
JO - Molecular Aspects of Medicine
JF - Molecular Aspects of Medicine
M1 - 101113
ER -
SDG 3 Good Health and Well-being