Treatment of the benzyl and (trimethylsilylethoxymethyl) SEM protected 2,2′-biimidazoles, 2a and 2b, with 2 equivalents of N-bromosuccinimide (NBS) allows obtaining the 5,5′-dibromo and 4,4′-dibromo substituted biimidazoles, 3a and 5b respectively. The use of 4 equivalents of NBS, followed by treatment of the corresponding tetrabromoderivatives 4a and 5b with butyl lithium (BuLi), yields the 4,4′-dibromoderivatives 5a (G=Bn) and 5b (G=SEM).

Original languageEnglish
Pages (from-to)733-735
Number of pages3
JournalJournal of Heterocyclic Chemistry
Issue number4
Publication statusPublished - 2002


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