Prognostic factors in pediatric sepsis study, from the spanish society of pediatric intensive care

David Vila Pérez, Iolanda Jordan, Elisabeth Esteban, Patricia García-Soler, Vega Murga, Vanesa Bonil, Irene Ortiz, Carlos Flores, Amaya Bustinza, Francisco Jose Cambra

Research output: Indexed journal article Articlepeer-review

28 Citations (Scopus)


BACKGROUND:: Sepsis and septic shock represent up to 30% of admitted patients in pediatric intensive care units, with a mortality that can exceed 10%. The objective of this study is to determine the prognostic factors for mortality in sepsis. METHODS:: Multicenter prospective descriptive study with patients (aged 7 days to 18 years) admitted to the pediatric intensive care units for sepsis, between January 2011 and April 2012. RESULTS:: Data from 136 patients were collected. Eighty-seven were male (63.9%). The median age was a year and a half (P25-75 0.3-5.5 years). In 41 cases (30.1%), there were underlying diseases. The most common etiology was Neisseria meningitidis (31 cases, 22.8%) followed by Streptococcus pneumoniae (16 patients, 11.8%). Seventeen cases were fatal (12.5%). In the statistical analysis, the factors associated with mortality were nosocomial infection (P = 0.004), hypotension (P <0.001) and heart and kidney failure (P < 0.001 and P = 0.004, respectively). The numbers of leukocytes, neutrophils and platelets on admission were statistically lower in the group that died (P was 0.006, 0.013 and <0.001, respectively). Multivariate analysis showed that multiple organ failure, neutropenia, purpura or coagulopathy and nosocomial infection were independent risk factors for increased mortality (odds ratio: 17, 4.9, 9 and 9.2, respectively). CONCLUSIONS:: Patients with sepsis and multiorgan failure, especially those with nosocomial infection or the presence of neutropenia or purpura, have a worse prognosis and should be monitored and treated early.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalPediatric Infectious Disease Journal
Issue number2
Publication statusPublished - 2014
Externally publishedYes


  • PIRO
  • SIRS
  • organ failure
  • prognostic
  • sepsis


Dive into the research topics of 'Prognostic factors in pediatric sepsis study, from the spanish society of pediatric intensive care'. Together they form a unique fingerprint.

Cite this