Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT ph-triggered delivery

Maria C. Llinàs, Gabriel Martínez-Edo, Anna Cascante, Irene Porcar, Salvador Borrós, David Sánchez-García*

*Corresponding author for this work

Research output: Indexed journal article Articlepeer-review

62 Citations (Scopus)

Abstract

A dual doxorubicin/camptothecin (DOX/CPT) pH-triggered drug delivery mesoporous silica nanoparticle (MSN)-based nano-vehicle has been prepared. In this drug-delivery system (DDS), CPT is loaded inside the pores of the MSNs, while DOX is covalently attached to the surface of an aldehyde-functionalized MSN through a dihydrazide–polyethylene glycol chain. Thus, DOX and the linker act as pH-sensitive gatekeeper. The system is versatile and easy to assemble, not requiring the chemical modification of the drugs. While at physiological conditions the release of the drugs is negligible, at acidic pH a burst release of DOX and a gradual release of CPT take place. In vitro cytotoxicity tests have demonstrated that this DDS can deliver efficiently DOX and CPT for combination therapy.

Original languageEnglish
Pages (from-to)1137-1146
Number of pages10
JournalDrug Delivery
Volume25
Issue number1
DOIs
Publication statusPublished - 2018

Keywords

  • Camptothecin
  • Combination therapy
  • Doxorubicin
  • Dual release
  • Mesoporous silica nanoparticles

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