Preparation and applications of organo-silica hybrid mesoporous silica nanoparticles for the co-delivery of drugs and nucleic acids

Iris Pontón, Andrea Martí del Rio, Marta Gómez Gómez, David Sánchez-García

Research output: Indexed journal article Reviewpeer-review

14 Citations (Scopus)

Abstract

Combination therapies rely on the administration of more than one drug, with independent mechanisms of action, aiming to enhance the efficiency of the treatment. For an optimal performance, the implementation of such therapies requires the delivery of the correct combination of drugs to a specific cellular target. In this context, the use of nanoparticles (NP) as platforms for the co-delivery of multiple drugs is considered a highly promising strategy. In particular, mesoporous silica nanoparticles (MSN) have emerged as versatile building blocks to devise complex drug delivery systems (DDS). This review describes the design, synthesis, and application of MSNs to the delivery of multiple drugs including nucleic acids for combination therapies.

Original languageEnglish
Article number2466
Pages (from-to)1-37
Number of pages37
JournalNanomaterials
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • Co-delivery
  • Combination therapies
  • Drug delivery
  • Mesoporous silica
  • Nanoparticles
  • RNA

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