Potential blood pressure thresholds and outcome in acute intracerebral hemorrhage

David Rodriguez-Luna; Marian Muchada; Socorro Piñeiro; Alan Flores; Marta Rubiera; Jorge Pagola; Pilar Coscojuela; Pilar Meler; Estela Sanjuan; Sandra Boned-Riera; Daniel A. Cárcamo; Alejandro Tomasello; Jose Alvarez-Sabin; Marc Ribo; Carlos A. Molina

doi:10.1159/000362269

Potential blood pressure thresholds and outcome in acute intracerebral hemorrhage

David Rodriguez-Luna, Marian Muchada, Socorro Piñeiro, Alan Flores, Marta Rubiera, Jorge Pagola, Pilar Coscojuela, Pilar Meler, Estela Sanjuan, Sandra Boned-Riera, Daniel A. Cárcamo, Alejandro Tomasello, Jose Alvarez-Sabin, Marc Ribo, Carlos A. Molina

Research output: Indexed journal article › Article › peer-review

4 Citations (Scopus)

Abstract

Background: Little is known about the relationships between different systolic blood pressure (SBP) thresholds and their outcomes in acute intracerebral hemorrhage (ICH). We aimed to determine the associations of potential systolic blood pressure (SBP) thresholds with hematoma growth (HG) and clinical outcome in patients with acute ICH.

Methods: 117 patients with acute (<6 h) spontaneous supratentorial ICH underwent blood pressure monitoring at 15 min interval over the first 24 h. SBP thresholds of 140, 150, 160, 170, 180, 190, and 200 mm Hg were assessed by means of the percentage of 24-hour values exceeding each threshold (SBP load). HG at 24 h, early neurological deterioration (END), 24-hour and 90-day mortality, and poor outcome were recorded.

Results: SBP 170, 180, 190, and 200 loads were significantly correlated with the amount of both absolute and relative hematoma enlargement at 24 h. In multivariate analyses, SBP 170 load was related to HG and END, while SBP 160 load was associated with mortality at 24 h. No thresholds were independently related to outcomes at 90 days.

Conclusion: In patients with acute ICH, SBP lowering to at least less than 160 mm Hg threshold may be needed to minimize the deleterious effect of high SBP on 24-hour outcomes. were independently related to outcomes at 90 days.

Original language	English
Pages (from-to)	203-208
Number of pages	6
Journal	European Neurology
Volume	72
DOIs	https://doi.org/10.1159/000362269
Publication status	Published - 7 Nov 2014
Externally published	Yes

Keywords

Blood pressure
Hematoma growth
Intracerebral hemorrhage
Outcome

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10.1159/000362269

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Rodriguez-Luna, D., Muchada, M., Piñeiro, S., Flores, A., Rubiera, M., Pagola, J., Coscojuela, P., Meler, P., Sanjuan, E., Boned-Riera, S., Cárcamo, D. A., Tomasello, A., Alvarez-Sabin, J., Ribo, M., & Molina, C. A. (2014). Potential blood pressure thresholds and outcome in acute intracerebral hemorrhage. European Neurology, 72, 203-208. https://doi.org/10.1159/000362269

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title = "Potential blood pressure thresholds and outcome in acute intracerebral hemorrhage",

abstract = "Background: Little is known about the relationships between different systolic blood pressure (SBP) thresholds and their outcomes in acute intracerebral hemorrhage (ICH). We aimed to determine the associations of potential systolic blood pressure (SBP) thresholds with hematoma growth (HG) and clinical outcome in patients with acute ICH.Methods: 117 patients with acute (<6 h) spontaneous supratentorial ICH underwent blood pressure monitoring at 15 min interval over the first 24 h. SBP thresholds of 140, 150, 160, 170, 180, 190, and 200 mm Hg were assessed by means of the percentage of 24-hour values exceeding each threshold (SBP load). HG at 24 h, early neurological deterioration (END), 24-hour and 90-day mortality, and poor outcome were recorded.Results: SBP 170, 180, 190, and 200 loads were significantly correlated with the amount of both absolute and relative hematoma enlargement at 24 h. In multivariate analyses, SBP 170 load was related to HG and END, while SBP 160 load was associated with mortality at 24 h. No thresholds were independently related to outcomes at 90 days.Conclusion: In patients with acute ICH, SBP lowering to at least less than 160 mm Hg threshold may be needed to minimize the deleterious effect of high SBP on 24-hour outcomes. were independently related to outcomes at 90 days.",

keywords = "Blood pressure, Hematoma growth, Intracerebral hemorrhage, Outcome",

author = "David Rodriguez-Luna and Marian Muchada and Socorro Pi{\~n}eiro and Alan Flores and Marta Rubiera and Jorge Pagola and Pilar Coscojuela and Pilar Meler and Estela Sanjuan and Sandra Boned-Riera and C{\'a}rcamo, {Daniel A.} and Alejandro Tomasello and Jose Alvarez-Sabin and Marc Ribo and Molina, {Carlos A.}",

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month = nov,

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doi = "10.1159/000362269",

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T1 - Potential blood pressure thresholds and outcome in acute intracerebral hemorrhage

AU - Rodriguez-Luna, David

AU - Muchada, Marian

AU - Piñeiro, Socorro

AU - Flores, Alan

AU - Rubiera, Marta

AU - Pagola, Jorge

AU - Coscojuela, Pilar

AU - Meler, Pilar

AU - Sanjuan, Estela

AU - Boned-Riera, Sandra

AU - Cárcamo, Daniel A.

AU - Tomasello, Alejandro

AU - Alvarez-Sabin, Jose

AU - Ribo, Marc

AU - Molina, Carlos A.

PY - 2014/11/7

Y1 - 2014/11/7

N2 - Background: Little is known about the relationships between different systolic blood pressure (SBP) thresholds and their outcomes in acute intracerebral hemorrhage (ICH). We aimed to determine the associations of potential systolic blood pressure (SBP) thresholds with hematoma growth (HG) and clinical outcome in patients with acute ICH.Methods: 117 patients with acute (<6 h) spontaneous supratentorial ICH underwent blood pressure monitoring at 15 min interval over the first 24 h. SBP thresholds of 140, 150, 160, 170, 180, 190, and 200 mm Hg were assessed by means of the percentage of 24-hour values exceeding each threshold (SBP load). HG at 24 h, early neurological deterioration (END), 24-hour and 90-day mortality, and poor outcome were recorded.Results: SBP 170, 180, 190, and 200 loads were significantly correlated with the amount of both absolute and relative hematoma enlargement at 24 h. In multivariate analyses, SBP 170 load was related to HG and END, while SBP 160 load was associated with mortality at 24 h. No thresholds were independently related to outcomes at 90 days.Conclusion: In patients with acute ICH, SBP lowering to at least less than 160 mm Hg threshold may be needed to minimize the deleterious effect of high SBP on 24-hour outcomes. were independently related to outcomes at 90 days.

AB - Background: Little is known about the relationships between different systolic blood pressure (SBP) thresholds and their outcomes in acute intracerebral hemorrhage (ICH). We aimed to determine the associations of potential systolic blood pressure (SBP) thresholds with hematoma growth (HG) and clinical outcome in patients with acute ICH.Methods: 117 patients with acute (<6 h) spontaneous supratentorial ICH underwent blood pressure monitoring at 15 min interval over the first 24 h. SBP thresholds of 140, 150, 160, 170, 180, 190, and 200 mm Hg were assessed by means of the percentage of 24-hour values exceeding each threshold (SBP load). HG at 24 h, early neurological deterioration (END), 24-hour and 90-day mortality, and poor outcome were recorded.Results: SBP 170, 180, 190, and 200 loads were significantly correlated with the amount of both absolute and relative hematoma enlargement at 24 h. In multivariate analyses, SBP 170 load was related to HG and END, while SBP 160 load was associated with mortality at 24 h. No thresholds were independently related to outcomes at 90 days.Conclusion: In patients with acute ICH, SBP lowering to at least less than 160 mm Hg threshold may be needed to minimize the deleterious effect of high SBP on 24-hour outcomes. were independently related to outcomes at 90 days.

KW - Blood pressure

KW - Hematoma growth

KW - Intracerebral hemorrhage

KW - Outcome

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U2 - 10.1159/000362269

DO - 10.1159/000362269

M3 - Article

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AN - SCOPUS:84910055583

SN - 0014-3022

VL - 72

SP - 203

EP - 208

JO - European Neurology

JF - European Neurology

ER -

Potential blood pressure thresholds and outcome in acute intracerebral hemorrhage

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Keywords

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