Polycomb-dependent control of cell fate in adult tissue

Pedro Vizán, Malte Beringer, Luciano Di Croce

Research output: Indexed journal article Articlepeer-review

4 Citations (Scopus)


Epigenetic control of gene expression in adult tissues is crucial to maintain organ function and homeostasis. A report in this issue of The EMBO Journal (Chiacchiera et al,), together with another one published in Gastroenterology (Koppens et al,), unveils how chromatin repressive complex PRC2 controls the equilibrium between secretory and absorptive fates in the intestine. PRC2 controls proliferation of cells within the crypt and at the same time represses the transcription factor Atoh1, thus favoring the generation of enterocytes versus secretory cell types in the adult intestine.

Original languageEnglish
Pages (from-to)2268-2269
Number of pages2
JournalEMBO Journal
Issue number21
Publication statusPublished - 2 Nov 2016
Externally publishedYes


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