Plasma 25-hydroxyvitamin D concentration and lymphoma risk: Results of the european prospective investigation into cancer and nutrition

Anna Łuczyńska; Rudolf Kaaks; Sabine Rohrmann; Susen Becker; Jakob Linseisen; Brian Buijsse; Kim Overvad; Antonia Trichopoulou; Elisavet Valanou; Antonia Barmpitsioti; Giovanna Masala; Claudia Agnoli; Rosario Tumino; Salvatore Panico; H. Bas Bueno-de-Mesquita; Fränzel J.B. Van Duijnhoven; Petra H.M. Peeters; Roel Vermeulen; Elisabete Weiderpass; Magritt Brustad; Guri Skeie; Carlos A. González; Paula Jakszyn; J. Ramón Quirós; María José Sánchez; José María Huerta; Eva Ardanaz; Beatrice Melin; Ann Sofie Johansson; Martin Almquist; Johan Malm; Kay Tee Khaw; Nick Wareham; Ruth C. Travis; Veronika Fedirko; Isabelle Romieu; Mazda Jenab; Valentina Gallo; Elio Riboli; Paolo Vineis; Alexandra Nieters

doi:10.3945/ajcn.112.054676

Plasma 25-hydroxyvitamin D concentration and lymphoma risk: Results of the european prospective investigation into cancer and nutrition

Anna Łuczyńska, Rudolf Kaaks, Sabine Rohrmann, Susen Becker, Jakob Linseisen, Brian Buijsse, Kim Overvad, Antonia Trichopoulou, Elisavet Valanou, Antonia Barmpitsioti, Giovanna Masala, Claudia Agnoli, Rosario Tumino, Salvatore Panico, H. Bas Bueno-de-Mesquita, Fränzel J.B. Van Duijnhoven, Petra H.M. Peeters, Roel Vermeulen, Elisabete Weiderpass, Magritt BrustadGuri Skeie, Carlos A. González, Paula Jakszyn, J. Ramón Quirós, María José Sánchez, José María Huerta, Eva Ardanaz, Beatrice Melin, Ann Sofie Johansson, Martin Almquist, Johan Malm, Kay Tee Khaw, Nick Wareham, Ruth C. Travis, Veronika Fedirko, Isabelle Romieu, Mazda Jenab, Valentina Gallo, Elio Riboli, Paolo Vineis, Alexandra Nieters^*

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

40 Citations (Scopus)

Abstract

Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and seasonspecific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (Pheterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with ≥2 y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.

Original language	English
Pages (from-to)	827-838
Number of pages	12
Journal	American Journal of Clinical Nutrition
Volume	98
Issue number	3
DOIs	https://doi.org/10.3945/ajcn.112.054676
Publication status	Published - 1 Sept 2013
Externally published	Yes

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Łuczyńska, A., Kaaks, R., Rohrmann, S., Becker, S., Linseisen, J., Buijsse, B., Overvad, K., Trichopoulou, A., Valanou, E., Barmpitsioti, A., Masala, G., Agnoli, C., Tumino, R., Panico, S., Bas Bueno-de-Mesquita, H., Van Duijnhoven, F. J. B., Peeters, P. H. M., Vermeulen, R., Weiderpass, E., ... Nieters, A. (2013). Plasma 25-hydroxyvitamin D concentration and lymphoma risk: Results of the european prospective investigation into cancer and nutrition. American Journal of Clinical Nutrition, 98(3), 827-838. https://doi.org/10.3945/ajcn.112.054676

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title = "Plasma 25-hydroxyvitamin D concentration and lymphoma risk: Results of the european prospective investigation into cancer and nutrition",

abstract = "Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and seasonspecific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (Pheterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with ≥2 y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.",

author = "Anna {\L}uczy{\'n}ska and Rudolf Kaaks and Sabine Rohrmann and Susen Becker and Jakob Linseisen and Brian Buijsse and Kim Overvad and Antonia Trichopoulou and Elisavet Valanou and Antonia Barmpitsioti and Giovanna Masala and Claudia Agnoli and Rosario Tumino and Salvatore Panico and {Bas Bueno-de-Mesquita}, H. and {Van Duijnhoven}, {Fr{\"a}nzel J.B.} and Peeters, {Petra H.M.} and Roel Vermeulen and Elisabete Weiderpass and Magritt Brustad and Guri Skeie and Gonz{\'a}lez, {Carlos A.} and Paula Jakszyn and {Ram{\'o}n Quir{\'o}s}, J. and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Huerta, {Jos{\'e} Mar{\'i}a} and Eva Ardanaz and Beatrice Melin and Johansson, {Ann Sofie} and Martin Almquist and Johan Malm and Khaw, {Kay Tee} and Nick Wareham and Travis, {Ruth C.} and Veronika Fedirko and Isabelle Romieu and Mazda Jenab and Valentina Gallo and Elio Riboli and Paolo Vineis and Alexandra Nieters",

year = "2013",

month = sep,

day = "1",

doi = "10.3945/ajcn.112.054676",

language = "English",

volume = "98",

pages = "827--838",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "Elsevier B.V.",

number = "3",

}

Łuczyńska, A, Kaaks, R, Rohrmann, S, Becker, S, Linseisen, J, Buijsse, B, Overvad, K, Trichopoulou, A, Valanou, E, Barmpitsioti, A, Masala, G, Agnoli, C, Tumino, R, Panico, S, Bas Bueno-de-Mesquita, H, Van Duijnhoven, FJB, Peeters, PHM, Vermeulen, R, Weiderpass, E, Brustad, M, Skeie, G, González, CA, Jakszyn, P, Ramón Quirós, J, Sánchez, MJ, Huerta, JM, Ardanaz, E, Melin, B, Johansson, AS, Almquist, M, Malm, J, Khaw, KT, Wareham, N, Travis, RC, Fedirko, V, Romieu, I, Jenab, M, Gallo, V, Riboli, E, Vineis, P & Nieters, A 2013, 'Plasma 25-hydroxyvitamin D concentration and lymphoma risk: Results of the european prospective investigation into cancer and nutrition', American Journal of Clinical Nutrition, vol. 98, no. 3, pp. 827-838. https://doi.org/10.3945/ajcn.112.054676

TY - JOUR

T1 - Plasma 25-hydroxyvitamin D concentration and lymphoma risk

T2 - Results of the european prospective investigation into cancer and nutrition

AU - Łuczyńska, Anna

AU - Kaaks, Rudolf

AU - Rohrmann, Sabine

AU - Becker, Susen

AU - Linseisen, Jakob

AU - Buijsse, Brian

AU - Overvad, Kim

AU - Trichopoulou, Antonia

AU - Valanou, Elisavet

AU - Barmpitsioti, Antonia

AU - Masala, Giovanna

AU - Agnoli, Claudia

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Bas Bueno-de-Mesquita, H.

AU - Van Duijnhoven, Fränzel J.B.

AU - Peeters, Petra H.M.

AU - Vermeulen, Roel

AU - Weiderpass, Elisabete

AU - Brustad, Magritt

AU - Skeie, Guri

AU - González, Carlos A.

AU - Jakszyn, Paula

AU - Ramón Quirós, J.

AU - Sánchez, María José

AU - Huerta, José María

AU - Ardanaz, Eva

AU - Melin, Beatrice

AU - Johansson, Ann Sofie

AU - Almquist, Martin

AU - Malm, Johan

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Travis, Ruth C.

AU - Fedirko, Veronika

AU - Romieu, Isabelle

AU - Jenab, Mazda

AU - Gallo, Valentina

AU - Riboli, Elio

AU - Vineis, Paolo

AU - Nieters, Alexandra

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and seasonspecific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (Pheterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with ≥2 y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.

AB - Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and seasonspecific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (Pheterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with ≥2 y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.

UR - http://www.scopus.com/inward/record.url?scp=84883143983&partnerID=8YFLogxK

U2 - 10.3945/ajcn.112.054676

DO - 10.3945/ajcn.112.054676

M3 - Article

C2 - 23885049

AN - SCOPUS:84883143983

SN - 0002-9165

VL - 98

SP - 827

EP - 838

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 3

ER -

Plasma 25-hydroxyvitamin D concentration and lymphoma risk: Results of the european prospective investigation into cancer and nutrition

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