TY - JOUR
T1 - Photosensitizing proteins for a targeted antibacterial photodynamic inactivation
AU - Mussini, A.
AU - Hally, C.
AU - Viappiani, C.
AU - Nonell, S.
AU - Agut Bonsfills, Montserrat
AU - Abbruzzetti, S.
N1 - Funding Information:
SA and CV acknowledge support from Azienda USL di Piacenza, Italy, and Fon-dazione di Piacenza e Vigevano. SN and MA acknowledge funding by the Spanish Government (MCIU/AEI/FEDER, UE; grant CTQ2016-78454-C2-1-R)
Publisher Copyright:
© 2021 Societa Italiana di Fisica. All rights reserved.
PY - 2021/7
Y1 - 2021/7
N2 - One of the emerging global health threats is the drug-resistant microbial diseases that could cause millions of deaths each year by 2050. A very promising tool to tackle antimicrobial resistance is photodynamic therapy that exploits the ability of a photosensitizer to generate oxidizing species upon illumination to kill bacteria. The research activity in this field is very active and, following this approach, we aim to develop a targeted theranostic agent where a protein is used as a “modular” carrier, transporting a fluorescent photosensitizer, and an antibody to confer selectivity to the photodynamic effect.
AB - One of the emerging global health threats is the drug-resistant microbial diseases that could cause millions of deaths each year by 2050. A very promising tool to tackle antimicrobial resistance is photodynamic therapy that exploits the ability of a photosensitizer to generate oxidizing species upon illumination to kill bacteria. The research activity in this field is very active and, following this approach, we aim to develop a targeted theranostic agent where a protein is used as a “modular” carrier, transporting a fluorescent photosensitizer, and an antibody to confer selectivity to the photodynamic effect.
UR - https://www.scopus.com/pages/publications/85112524970
UR - http://hdl.handle.net/20.500.14342/4553
U2 - 10.1393/ncc/i2021-21122-6
DO - 10.1393/ncc/i2021-21122-6
M3 - Article
AN - SCOPUS:85112524970
SN - 2037-4909
VL - 44
JO - Nuovo Cimento della Societa Italiana di Fisica C
JF - Nuovo Cimento della Societa Italiana di Fisica C
IS - 4-5
M1 - 122
ER -