Photosensitisers for photodynamic therapy: State of the art and perspectives

Beatriz Rodríguez Amigo, Oriol Planas Marques, Roger Bresoli Obach, Joaquim Torra Nonell, Ruben Ruiz Gonzalez, Santiago Nonell Marrugat

Research output: Book chapterChapter

Abstract

Photodynamic therapy relies on the action of a photosensitising drug in order to generate reactive oxygen species that cause damage to biological cells and tissues. The key aspects for the success of this therapy are the optical and photosensitising properties of the drug, as well as its pharmacological properties. This chapter provides an overview of the drugs already approved for clinical use for cancer, antimicrobial or other applications, as well as a list of those in clinical trials and at the preclinical stage. Emerging strategies for controlling the production of reactive oxygen species and novel photosensitising modalities brought about by the bio- and nano-revolutions are discussed.
Translated title of the contributionPhotosensitisers for photodynamic therapy: State of the art and perspectives
Original languageEnglish
Title of host publicationPhotodynamic Medicine: From bench to clinic
EditorsHerwig Kostron, Tayyaba Hasan
PublisherRoyal Society of Chemistry
Chapter2
Pages23-62
Number of pages39
ISBN (Electronic)978-1-78262-823-1, 978-1-78262-682-4
ISBN (Print)978-1-78262-451-6
DOIs
Publication statusPublished - 2016

Publication series

NameComprehensive Series in Photochemical & Photobiological Sciences
ISSN (Print)2041-9716
ISSN (Electronic)2041-9724

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