Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals

Eduardo Anaya-Plaza; Eveline van de Winckel; Joona Mikkilä; Jani Markus Malho; Olli Ikkala; Oscar Gulías; Roger Bresolí-Obach; Montserrat Agut; Santi Nonell; Tomás Torres; Mauri A. Kostiainen; Andrés de la Escosura

doi:10.1002/chem.201605285

Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals

Eduardo Anaya-Plaza, Eveline van de Winckel, Joona Mikkilä, Jani Markus Malho, Olli Ikkala, Oscar Gulías, Roger Bresolí-Obach, Montserrat Agut, Santi Nonell, Tomás Torres^*, Mauri A. Kostiainen, Andrés de la Escosura

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

41 Citations (Scopus)

Abstract

The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.

Original language	English
Pages (from-to)	4320-4326
Number of pages	7
Journal	Chemistry - A European Journal
Volume	23
Issue number	18
DOIs	https://doi.org/10.1002/chem.201605285
Publication status	Published - 28 Mar 2017

Keywords

cellulose nanocrystals
functional materials
photoantimicrobial biohybrids
phthalocyanine
supramolecular complex

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10.1002/chem.201605285

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Anaya-Plaza, E., van de Winckel, E., Mikkilä, J., Malho, J. M., Ikkala, O., Gulías, O., Bresolí-Obach, R., Agut, M., Nonell, S., Torres, T., Kostiainen, M. A., & de la Escosura, A. (2017). Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals. Chemistry - A European Journal, 23(18), 4320-4326. https://doi.org/10.1002/chem.201605285

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abstract = "The development of photoactive and biocompatible nanostructures is a highly desirable goal to address the current threat of antibiotic resistance. Here, we describe a novel supramolecular biohybrid nanostructure based on the non-covalent immobilization of cationic zinc phthalocyanine (ZnPc) derivatives onto unmodified cellulose nanocrystals (CNC), following an easy and straightforward protocol, in which binding is driven by electrostatic interactions. These non-covalent biohybrids show strong photodynamic activity against S. aureus and E. coli, representative examples of Gram-positive and Gram-negative bacteria, respectively, and C. albicans, a representative opportunistic fungal pathogen, outperforming the free ZnPc counterparts and related nanosystems in which the photosensitizer is covalently linked to the CNC surface.",

keywords = "cellulose nanocrystals, functional materials, photoantimicrobial biohybrids, phthalocyanine, supramolecular complex",

author = "Eduardo Anaya-Plaza and {van de Winckel}, Eveline and Joona Mikkil{\"a} and Malho, {Jani Markus} and Olli Ikkala and Oscar Gul{\'i}as and Roger Bresol{\'i}-Obach and Montserrat Agut and Santi Nonell and Tom{\'a}s Torres and Kostiainen, {Mauri A.} and {de la Escosura}, Andr{\'e}s",

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Anaya-Plaza, E, van de Winckel, E, Mikkilä, J, Malho, JM, Ikkala, O, Gulías, O , Bresolí-Obach, R , Agut, M , Nonell, S, Torres, T, Kostiainen, MA & de la Escosura, A 2017, 'Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals', Chemistry - A European Journal, vol. 23, no. 18, pp. 4320-4326. https://doi.org/10.1002/chem.201605285

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AU - Malho, Jani Markus

AU - Ikkala, Olli

AU - Gulías, Oscar

AU - Bresolí-Obach, Roger

AU - Agut, Montserrat

AU - Nonell, Santi

AU - Torres, Tomás

AU - Kostiainen, Mauri A.

AU - de la Escosura, Andrés

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Photoantimicrobial Biohybrids by Supramolecular Immobilization of Cationic Phthalocyanines onto Cellulose Nanocrystals

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Keywords

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