Penetration of morphine and naloxone in phosphatidylserine monolayers

F. Reig, C. Mestres, J. M.García Antón, G. Valencia, M. A. Alsina

Research output: Indexed journal article Articlepeer-review

4 Citations (Scopus)


The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m-1.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalInternational Journal of Pharmaceutics
Issue number1-3
Publication statusPublished - Jun 1988
Externally publishedYes


  • Adsorption kinetics
  • Monolayer
  • Opiate-phospholipid interaction


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