Penetration of morphine and naloxone in phosphatidylserine monolayers

F. Reig; C. Mestres; J. M.García Antón; G. Valencia; M. A. Alsina

doi:10.1016/0378-5173(88)90126-3

Penetration of morphine and naloxone in phosphatidylserine monolayers

F. Reig, C. Mestres, J. M.García Antón, G. Valencia, M. A. Alsina

Research output: Indexed journal article › Article › peer-review

4 Citations (Scopus)

Abstract

The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m^-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m^-1.

Original language	English
Pages (from-to)	269-272
Number of pages	4
Journal	International Journal of Pharmaceutics
Volume	44
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-5173(88)90126-3
Publication status	Published - Jun 1988
Externally published	Yes

Keywords

Adsorption kinetics
Monolayer
Opiate-phospholipid interaction

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10.1016/0378-5173(88)90126-3

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abstract = "The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m-1.",

keywords = "Adsorption kinetics, Monolayer, Opiate-phospholipid interaction",

author = "F. Reig and C. Mestres and Ant{\'o}n, {J. M.Garc{\'i}a} and G. Valencia and Alsina, {M. A.}",

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T1 - Penetration of morphine and naloxone in phosphatidylserine monolayers

AU - Reig, F.

AU - Mestres, C.

AU - Antón, J. M.García

AU - Valencia, G.

AU - Alsina, M. A.

PY - 1988/6

Y1 - 1988/6

N2 - The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m-1.

AB - The interaction between morphine or naloxone and phosphatidylserine (PS), has been studied using monomolecular layers as membrane model. The penetration kinetics of both molecules measured at different monolayer pressures and for increasing opiate concentrations has been determined. The results show that penetration of morphine presents a maximum at 15 mN · m-1 of initial PS pressure whereas that of naloxone has a maximum at 10 mN · m-1.

KW - Adsorption kinetics

KW - Monolayer

KW - Opiate-phospholipid interaction

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U2 - 10.1016/0378-5173(88)90126-3

DO - 10.1016/0378-5173(88)90126-3

M3 - Article

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VL - 44

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EP - 272

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-3

ER -

Penetration of morphine and naloxone in phosphatidylserine monolayers

Abstract

Keywords

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