Abstract
A long-range optimized P.E.HSQC experiment, named P.E.HSQMBC, is proposed for the simultaneous measurement of a complete set of homonuclear and heteronuclear coupling constants from a single 2D cross-peak. The sign and the magnitude of proton-proton coupling constants are measured along the direct dimension from the relative E.COSY-type multiplet pattern displacement due to the passive one-bond coupling constant splitting generated in the indirect dimension. On the other hand, long-range proton-carbon coupling constants are independently determined in the detected dimension from a traditional fitting analysis of antiphase multiplet patterns or, more conveniently, from the IPAP multiplet displacement obtained from extended HSQMBC experiments.
Original language | English |
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Pages (from-to) | 101-106 |
Number of pages | 6 |
Journal | Journal of Magnetic Resonance |
Volume | 224 |
DOIs | |
Publication status | Published - Nov 2012 |
Externally published | Yes |
Keywords
- E.COSY
- HSQMBC
- IPAP
- Long-range proton-carbon coupling constants
- Proton-proton coupling constants