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Novel Chitosan-Riboflavin Conjugate with Visible Light-Enhanced Antifungal Properties against Penicillium digitatum

  • Luciano Dibona-Villanueva
  • , Denis Fuentealba*
  • *Corresponding author for this work

Research output: Indexed journal article Articlepeer-review

27 Citations (Scopus)

Abstract

A novel chemical conjugate between chitosan (CH) and riboflavin (RF) has been synthesized and characterized via Fourier transform infrared, NMR, and other spectroscopic methods. Photophysical and photochemical properties such as absorption spectra, fluorescence emission, fluorescence anisotropy, and singlet oxygen generation were characterized as well. This new biopolymer-based conjugate was designed to have an antifungal effect enhanced through antimicrobial photodynamic therapy. The antifungal effect of this conjugate (CH-RF) was compared with CH and RF against Penicillium digitatum in vitro. The conjugate showed the highest fungal growth inhibition of all systems tested at a dose of 0.5% w/v. This new biopolymer-based compound could be a promising alternative to fungicides used in citrus fruits postharvest.

Original languageEnglish
Pages (from-to)945-954
Number of pages10
JournalJournal of Agricultural and Food Chemistry
Volume69
Issue number3
DOIs
Publication statusPublished - 27 Jan 2021
Externally publishedYes

Keywords

  • antifungal
  • antimicrobial photodynamic therapy
  • chemical conjugate
  • chitosan
  • penicillium digitatum
  • riboflavin

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