Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury

Claudio Pizzolato; Dinesh B. Palipana; Kyle Mulholland; Alastair R. J. Quinn; Malik M. N. Mannan; Kelly Clanchy; Claire B. Crossley; Evan Jurd; Surendran Sabapathy; Leanne Bisset; Ewan C. R. Lloyd; Belinda Beck; Ana C. C. de Sousa; Yang D. Teng; David G. Lloyd

doi:10.1007/978-3-031-77584-0_13

Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury

Claudio Pizzolato
, Dinesh B. Palipana
, Kyle Mulholland
, Alastair R. J. Quinn
, Malik M. N. Mannan
, Kelly Clanchy
, Claire B. Crossley
, Evan Jurd
, Surendran Sabapathy
, Leanne Bisset
, Ewan C. R. Lloyd
, Belinda Beck
, Ana C. C. de Sousa
, Yang D. Teng
, David G. Lloyd

Research output: Book chapter › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Spinal cord injury (SCI) disrupts communication between high brain centers and the peripheral neuromusculoskeletal system, resulting in debilitating sensorimotor impairment, autonomic dysfunction, and musculoskeletal degeneration. To repair these concurrent deficits, we developed a multimodal rehabilitation system comprising a brain-computer interface (BCI), lower limbs functional electrical stimulation (FES), and virtual reality (VR) feedback. The apparatus, devised on a motorised semi-recumbent cycling ergometer, is controlled by a real-time digital twin of the user. Four individuals with chronic complete SCI have finished our year-1 study. While all participants gained discernible sensory, autonomic, muscular, and bone mineral density improvements, two of them additionally attained significant somatomotor benefits and recovered ability to voluntary contract previously paralysed muscles.

Original language	English
Title of host publication	Converging Clinical And Engineering Research On Neurorehabilitation V, Icnr 2024, Vol 2
Editors	JL Pons, J Tornero, M Akay
Publisher	Springer Nature
Pages	63-67
Number of pages	5
Volume	32
ISBN (Electronic)	978-3-031-77584-0
ISBN (Print)	978-3-031-77586-4, 978-3-031-77583-3
DOIs	https://doi.org/10.1007/978-3-031-77584-0_13
Publication status	Published - 2024
Externally published	Yes
Event	6th International Conference on Neurorehabilitation - , Spain Duration: 5 Nov 2024 → 8 Nov 2024

Publication series

Name	Biosystems And Biorobotics
Volume	32
ISSN (Print)	2195-3562
ISSN (Electronic)	2195-3570

Conference

Conference	6th International Conference on Neurorehabilitation
Country/Territory	Spain
Period	5/11/24 → 8/11/24

Access to Document

10.1007/978-3-031-77584-0_13

Cite this

Pizzolato, C., Palipana, D. B., Mulholland, K., Quinn, A. R. J., Mannan, M. M. N., Clanchy, K., Crossley, C. B., Jurd, E., Sabapathy, S., Bisset, L., Lloyd, E. C. R., Beck, B., de Sousa, A. C. C., Teng, Y. D., & Lloyd, D. G. (2024). Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury. In JL. Pons, J. Tornero, & M. Akay (Eds.), Converging Clinical And Engineering Research On Neurorehabilitation V, Icnr 2024, Vol 2 (Vol. 32, pp. 63-67). (Biosystems And Biorobotics; Vol. 32). Springer Nature. https://doi.org/10.1007/978-3-031-77584-0_13

Pizzolato, Claudio ; Palipana, Dinesh B. ; Mulholland, Kyle et al. / Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury. Converging Clinical And Engineering Research On Neurorehabilitation V, Icnr 2024, Vol 2. editor / JL Pons ; J Tornero ; M Akay. Vol. 32 Springer Nature, 2024. pp. 63-67 (Biosystems And Biorobotics).

@inproceedings{5cbf1618c6814428b016cd123a3e3250,

title = "Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury",

abstract = "Spinal cord injury (SCI) disrupts communication between high brain centers and the peripheral neuromusculoskeletal system, resulting in debilitating sensorimotor impairment, autonomic dysfunction, and musculoskeletal degeneration. To repair these concurrent deficits, we developed a multimodal rehabilitation system comprising a brain-computer interface (BCI), lower limbs functional electrical stimulation (FES), and virtual reality (VR) feedback. The apparatus, devised on a motorised semi-recumbent cycling ergometer, is controlled by a real-time digital twin of the user. Four individuals with chronic complete SCI have finished our year-1 study. While all participants gained discernible sensory, autonomic, muscular, and bone mineral density improvements, two of them additionally attained significant somatomotor benefits and recovered ability to voluntary contract previously paralysed muscles.",

author = "Claudio Pizzolato and Palipana, \{Dinesh B.\} and Kyle Mulholland and Quinn, \{Alastair R. J.\} and Mannan, \{Malik M. N.\} and Kelly Clanchy and Crossley, \{Claire B.\} and Evan Jurd and Surendran Sabapathy and Leanne Bisset and Lloyd, \{Ewan C. R.\} and Belinda Beck and \{de Sousa\}, \{Ana C. C.\} and Teng, \{Yang D.\} and Lloyd, \{David G.\}",

year = "2024",

doi = "10.1007/978-3-031-77584-0\_13",

language = "English",

isbn = "978-3-031-77586-4",

volume = "32",

series = "Biosystems And Biorobotics",

publisher = "Springer Nature",

pages = "63--67",

editor = "JL Pons and J Tornero and M Akay",

booktitle = "Converging Clinical And Engineering Research On Neurorehabilitation V, Icnr 2024, Vol 2",

address = "United Kingdom",

note = "6th International Conference on Neurorehabilitation ; Conference date: 05-11-2024 Through 08-11-2024",

}

Pizzolato, C, Palipana, DB, Mulholland, K, Quinn, ARJ, Mannan, MMN, Clanchy, K, Crossley, CB, Jurd, E, Sabapathy, S, Bisset, L, Lloyd, ECR, Beck, B, de Sousa, ACC, Teng, YD & Lloyd, DG 2024, Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury. in JL Pons, J Tornero & M Akay (eds), Converging Clinical And Engineering Research On Neurorehabilitation V, Icnr 2024, Vol 2. vol. 32, Biosystems And Biorobotics, vol. 32, Springer Nature, pp. 63-67, 6th International Conference on Neurorehabilitation, Spain, 5/11/24. https://doi.org/10.1007/978-3-031-77584-0_13

Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury. / Pizzolato, Claudio; Palipana, Dinesh B.; Mulholland, Kyle et al.
Converging Clinical And Engineering Research On Neurorehabilitation V, Icnr 2024, Vol 2. ed. / JL Pons; J Tornero; M Akay. Vol. 32 Springer Nature, 2024. p. 63-67 (Biosystems And Biorobotics; Vol. 32).

Research output: Book chapter › Conference contribution › peer-review

TY - GEN

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AU - Pizzolato, Claudio

AU - Palipana, Dinesh B.

AU - Mulholland, Kyle

AU - Quinn, Alastair R. J.

AU - Mannan, Malik M. N.

AU - Clanchy, Kelly

AU - Crossley, Claire B.

AU - Jurd, Evan

AU - Sabapathy, Surendran

AU - Bisset, Leanne

AU - Lloyd, Ewan C. R.

AU - Beck, Belinda

AU - de Sousa, Ana C. C.

AU - Teng, Yang D.

AU - Lloyd, David G.

PY - 2024

Y1 - 2024

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AB - Spinal cord injury (SCI) disrupts communication between high brain centers and the peripheral neuromusculoskeletal system, resulting in debilitating sensorimotor impairment, autonomic dysfunction, and musculoskeletal degeneration. To repair these concurrent deficits, we developed a multimodal rehabilitation system comprising a brain-computer interface (BCI), lower limbs functional electrical stimulation (FES), and virtual reality (VR) feedback. The apparatus, devised on a motorised semi-recumbent cycling ergometer, is controlled by a real-time digital twin of the user. Four individuals with chronic complete SCI have finished our year-1 study. While all participants gained discernible sensory, autonomic, muscular, and bone mineral density improvements, two of them additionally attained significant somatomotor benefits and recovered ability to voluntary contract previously paralysed muscles.

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SN - 978-3-031-77586-4

SN - 978-3-031-77583-3

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T3 - Biosystems And Biorobotics

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T2 - 6th International Conference on Neurorehabilitation

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ER -

Pizzolato C, Palipana DB, Mulholland K, Quinn ARJ, Mannan MMN, Clanchy K et al. Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury. In Pons JL, Tornero J, Akay M, editors, Converging Clinical And Engineering Research On Neurorehabilitation V, Icnr 2024, Vol 2. Vol. 32. Springer Nature. 2024. p. 63-67. (Biosystems And Biorobotics). doi: 10.1007/978-3-031-77584-0_13

Non-invasive Digital Twin Controlled BCI-FES-VR Leg-Cycling Ergometer Intervention Recovers Sensorimotor Function in Individuals with Complete Spinal Cord Injury

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