Neurodevelopmental Outcomes of Mycotoxins Exposure and Effect on Brain Development in Infants and Young Children

Laure Viviane Ndam Ngoungoure; Wilfred Angie Abia; Brice Vincent Ayissi Owona; Yacouba Foupouapouognigni; Ferdinand Kouoh Elombo; Herman Philipe Njitoyap Nfombouot; Epole Ngolle Ntungwe; Frederic N. Njayou; Angéle N. Tchana; Paul F. Moundipa

doi:10.1002/dneu.23000

Neurodevelopmental Outcomes of Mycotoxins Exposure and Effect on Brain Development in Infants and Young Children

Laure Viviane Ndam Ngoungoure
, Wilfred Angie Abia^*
, Brice Vincent Ayissi Owona
, Yacouba Foupouapouognigni
, Ferdinand Kouoh Elombo
, Herman Philipe Njitoyap Nfombouot
, Epole Ngolle Ntungwe
, Frederic N. Njayou
, Angéle N. Tchana
, Paul F. Moundipa

^*Corresponding author for this work

Research output: Indexed journal article › Review › peer-review

Abstract

This comprehensive literature review was conducted to identify relevant studies on mycotoxins and brain development in children. Existing studies suggest that mycotoxin exposure during critical periods of brain development may lead to neurocognitive impairments in children. Some studies have reported associations between mycotoxin exposure and reduced cognitive abilities, impaired motor skills, and behavioral problems. Additionally, mycotoxins have been shown to disrupt neural signaling pathways and interfere with neurotransmitter function, potentially contributing to neurodevelopmental disorders. This comprehensive review has provided a comprehensive overview of the possible evidence on the association between mycotoxin exposure and brain development in children and identified areas for future research.

Original language	English
Article number	e23000
Number of pages	16
Journal	Developmental Neurobiology
Volume	85
Issue number	4
DOIs	https://doi.org/10.1002/dneu.23000
Publication status	Published - Oct 2025

Keywords

brain development
cognitive
motor and learning impairments
mycotoxins
neurodevelopmental disorders

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10.1002/dneu.23000

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Ngoungoure, L. V. N., Abia, W. A., Owona, B. V. A., Foupouapouognigni, Y., Elombo, F. K., Nfombouot, H. P. N., Ntungwe, E. N., Njayou, F. N., Tchana, A. N., & Moundipa, P. F. (2025). Neurodevelopmental Outcomes of Mycotoxins Exposure and Effect on Brain Development in Infants and Young Children. Developmental Neurobiology, 85(4), Article e23000. https://doi.org/10.1002/dneu.23000

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title = "Neurodevelopmental Outcomes of Mycotoxins Exposure and Effect on Brain Development in Infants and Young Children",

abstract = "This comprehensive literature review was conducted to identify relevant studies on mycotoxins and brain development in children. Existing studies suggest that mycotoxin exposure during critical periods of brain development may lead to neurocognitive impairments in children. Some studies have reported associations between mycotoxin exposure and reduced cognitive abilities, impaired motor skills, and behavioral problems. Additionally, mycotoxins have been shown to disrupt neural signaling pathways and interfere with neurotransmitter function, potentially contributing to neurodevelopmental disorders. This comprehensive review has provided a comprehensive overview of the possible evidence on the association between mycotoxin exposure and brain development in children and identified areas for future research.",

keywords = "brain development, cognitive, motor and learning impairments, mycotoxins, neurodevelopmental disorders",

author = "Ngoungoure, \{Laure Viviane Ndam\} and Abia, \{Wilfred Angie\} and Owona, \{Brice Vincent Ayissi\} and Yacouba Foupouapouognigni and Elombo, \{Ferdinand Kouoh\} and Nfombouot, \{Herman Philipe Njitoyap\} and Ntungwe, \{Epole Ngolle\} and Njayou, \{Frederic N.\} and Tchana, \{Ang{\'e}le N.\} and Moundipa, \{Paul F.\}",

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doi = "10.1002/dneu.23000",

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AU - Ngoungoure, Laure Viviane Ndam

AU - Abia, Wilfred Angie

AU - Owona, Brice Vincent Ayissi

AU - Foupouapouognigni, Yacouba

AU - Elombo, Ferdinand Kouoh

AU - Nfombouot, Herman Philipe Njitoyap

AU - Ntungwe, Epole Ngolle

AU - Njayou, Frederic N.

AU - Tchana, Angéle N.

AU - Moundipa, Paul F.

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N2 - This comprehensive literature review was conducted to identify relevant studies on mycotoxins and brain development in children. Existing studies suggest that mycotoxin exposure during critical periods of brain development may lead to neurocognitive impairments in children. Some studies have reported associations between mycotoxin exposure and reduced cognitive abilities, impaired motor skills, and behavioral problems. Additionally, mycotoxins have been shown to disrupt neural signaling pathways and interfere with neurotransmitter function, potentially contributing to neurodevelopmental disorders. This comprehensive review has provided a comprehensive overview of the possible evidence on the association between mycotoxin exposure and brain development in children and identified areas for future research.

AB - This comprehensive literature review was conducted to identify relevant studies on mycotoxins and brain development in children. Existing studies suggest that mycotoxin exposure during critical periods of brain development may lead to neurocognitive impairments in children. Some studies have reported associations between mycotoxin exposure and reduced cognitive abilities, impaired motor skills, and behavioral problems. Additionally, mycotoxins have been shown to disrupt neural signaling pathways and interfere with neurotransmitter function, potentially contributing to neurodevelopmental disorders. This comprehensive review has provided a comprehensive overview of the possible evidence on the association between mycotoxin exposure and brain development in children and identified areas for future research.

KW - brain development

KW - cognitive

KW - motor and learning impairments

KW - mycotoxins

KW - neurodevelopmental disorders

UR - https://www.scopus.com/pages/publications/105014731897

UR - http://hdl.handle.net/20.500.14342/5676

U2 - 10.1002/dneu.23000

DO - 10.1002/dneu.23000

M3 - Review

AN - SCOPUS:105014731897

SN - 1932-8451

VL - 85

JO - Developmental Neurobiology

JF - Developmental Neurobiology

IS - 4

M1 - e23000

ER -

Neurodevelopmental Outcomes of Mycotoxins Exposure and Effect on Brain Development in Infants and Young Children

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