Multimodal prehabilitation in heart transplant recipients improves short-term post-transplant outcomes without increasing costs

Manuel López-Baamonde, María José Arguis, Ricard Navarro-Ripoll, Elena Gimeno-Santos, Bárbara Romano-Andrioni, Marina Sisó, Silvia Terès-Bellès, Antonio López-Hernández, Adrià Burniol-García, Marta Farrero, Raquel Sebio-García, Elena Sandoval, María Sanz-de la Garza, Julián Librero, Ana García-Álvarez, María Ángeles Castel, Graciela Martínez-Pallí

Research output: Indexed journal article Articlepeer-review

3 Citations (Scopus)


Background and aim: This study aimed to investigate the impact of prehabilitation on the postoperative outcomes of heart transplantation and its cost-effectiveness. 

Methods: This single-center, ambispective cohort study included forty-six candidates for elective heart transplantation from 2017 to 2021 attending a multimodal prehabilitation program consisting of supervised exercise training, physical activity promotion, nutritional optimization, and psychological support. The postoperative course was compared to a control cohort consisting of patients transplanted from 2014 to 2017 and those contemporaneously not involved in prehabilitation. 

Results: A significant improvement was observed in preoperative functional capacity (endurance time 281 vs. 728 s, p < 0.001) and quality-of-life (Minnesota score 58 vs. 47, p = 0.046) after the program. No exercise-related events were registered. The prehabilitation cohort showed a lower rate and severity of postoperative complications (comprehensive complication index 37 vs. 31, p = 0.033), lower mechanical ventilation time (37 vs. 20 h, p = 0.032), ICU stay (7 vs. 5 days, p = 0.01), total hospitalization stay (23 vs. 18 days, p = 0.008) and less need for transfer to nursing/rehabilitation facilities after hospital discharge (31% vs. 3%, p = 0.009). A cost-consequence analysis showed that prehabilitation did not increase the total surgical process costs.

Conclusions: Multimodal prehabilitation before heart transplantation has benefits on short-term postoperative outcomes potentially attributable to enhancement of physical status, without cost-increasing.

Original languageEnglish
Article number3724
Number of pages18
JournalJournal of clinical medicine
Issue number11
Publication statusPublished - Jun 2023


  • aerobic capacity
  • cost-analysis
  • heart transplantation
  • postoperative complications
  • prehabilitation
  • preoperative optimization
  • Cost-analysis
  • Preoperative optimization
  • Prehabilitation
  • Heart transplantation
  • Aerobic capacity
  • Postoperative complications


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