MMP-2/MMP-9 plasma level and brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke

Mar Hernandez-Guillamon, Elena Martinez-Saez, Pilar Delgado, Sophie Domingues-Montanari, Cristina Boada, Anna Penalba, Mercè Boada, Jorge Pagola, Olga Maisterra, David Rodriguez-Luna, Carlos A. Molina, Alex Rovira, José Alvarez-Sabin, Arantxa Ortega-Aznar, Joan Montaner

Research output: Indexed journal article Articlepeer-review

74 Citations (Scopus)

Abstract

Cerebral amyloid angiopathy (CAA) is one of the main causes of intracerebral hemorrhage (ICH) in the elderly. Matrix metalloproteinases (MMPs) have been implicated in blood-brain barrier disruption and ICH pathogenesis. In this study, we determined the levels MMP-2 and MMP-9 in plasma and their brain expression in CAA-associated hemorrhagic stroke. Although MMP-2 and MMP-9 plasma levels did not differ among patients and controls, their brain expression was increased in perihematoma areas of CAA-related hemorrhagic strokes compared with contralateral areas and nonhemorrhagic brains. In addition, MMP-2 reactivity was found in β-amyloid (Aβ)-damaged vessels located far from the acute ICH and in chronic microbleeds. MMP-2 expression was associated to endothelial cells, histiocytes and reactive astrocytes, whereas MMP-9 expression was restricted to inflammatory cells. In summary, MMP-2 expression within and around Aβ-compromised vessels might contribute to the vasculature fatal fate, triggering an eventual bleeding.

Original languageEnglish
Pages (from-to)133-141
Number of pages9
JournalBrain Pathology
Volume22
Issue number2
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

Keywords

  • MMP-2
  • MMP-9
  • cerebral amyloid angiopathy
  • hemorrhagic stroke
  • intracerebral hemorrhage
  • matrix metalloproteinase

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