Mixed monolayers composed of PC/PS/Chol. Interaction with opioid molecules

F. Reig*, C. Mestres, I. Haro, G. Valencia, J. M.García Antón, M. A. Alsina

*Corresponding author for this work

Research output: Indexed journal article Articlepeer-review

8 Citations (Scopus)

Abstract

The miscibility of phosphatidylserine, phosphatidylcholine, and cholesterol in monolayers were studied. The influence of sodium and calcium ions in this system was determined. The compression isotherms of mixed monolayers of the above cited three components spread on subphases containing opiate molecules are elucidated. Moreover, the penetration kinetics of opiate molecules in these mixed monolayers was also recorded. The results show that the presence of cholesterol always lowers the penetration of opioid molecules; this effect is weaken for meperidine, the most hydrophobic of the molecules assayed.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalColloid and Polymer Science
Volume267
Issue number2
DOIs
Publication statusPublished - Feb 1989
Externally publishedYes

Keywords

  • Opiates
  • cholesterol
  • monolayers
  • penetration kinetics
  • phosphatidylcholine
  • phosphatidylserine

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