Isothiocyanate-functionalized mesoporous silica nanoparticles as building blocks for the design of nanovehicles with optimized drug release profile

Gabriel Martínez-Edo, Maria C. Llinàs, Salvador Borrós, David Sánchez-García

Research output: Indexed journal article Articlepeer-review

12 Citations (Scopus)

Abstract

A straightforward methodology for the synthesis of isothiocyanate-functionalized mesoporous silica nanoparticles (MSNs) by exposure of aminated MSNs to 1,1-thiocarbonyldi-2(1H)-pyridone is reported. These nanoparticles are chemically stable, water tolerant, and readily react with primary amines without the formation of any by-product. This feature allows the easy modification of the surface of the nanoparticles for tuning their physical properties and the introduction of gatekeepers on the pore outlets. As a proof-of-concept, amino-isothiocyanate-functionalized MSNs have been used for the design of a nanocontainer able to release the drug Ataluren. The release profile of the drug can be easily fine-tuned with the careful choice of the capping amine.

Original languageEnglish
Article number1219
JournalNanomaterials
Volume9
Issue number9
DOIs
Publication statusPublished - Sept 2019

Keywords

  • Drug delivery
  • Isothiocyanate
  • Mesoporous silica nanoparticles
  • Regioselective functionalization

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