Interactions of naloxone with lipid monolayers

C. Mestres; F. Reig; M. A. Busquets; I. Haro; M. A. Alsina

doi:10.1016/0378-5173(91)90352-O

Interactions of naloxone with lipid monolayers

C. Mestres, F. Reig^*, M. A. Busquets, I. Haro, M. A. Alsina

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

1 Citation (Scopus)

Abstract

The interaction between an opioid antagonist, naloxone, and several lipids and lipid mixtures was studied using monomolecular layers as a membrane model. No specific interactions could be detected. The main factor affecting the penetration of naloxone in monolayers seems to be the initial ordered state of the molecules instead of the chemical composition of the monolayer. A new membrane model was assayed based on the retention times in high-pressure liquid chromatography working with hydrophobically modified columns.

Original language	English
Pages (from-to)	145-149
Number of pages	5
Journal	International Journal of Pharmaceutics
Volume	76
Issue number	1-2
DOIs	https://doi.org/10.1016/0378-5173(91)90352-O
Publication status	Published - 30 Sept 1991
Externally published	Yes

Keywords

HPLC
Monolayer
Naloxone
Sulfatide

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10.1016/0378-5173(91)90352-O

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title = "Interactions of naloxone with lipid monolayers",

abstract = "The interaction between an opioid antagonist, naloxone, and several lipids and lipid mixtures was studied using monomolecular layers as a membrane model. No specific interactions could be detected. The main factor affecting the penetration of naloxone in monolayers seems to be the initial ordered state of the molecules instead of the chemical composition of the monolayer. A new membrane model was assayed based on the retention times in high-pressure liquid chromatography working with hydrophobically modified columns.",

keywords = "HPLC, Monolayer, Naloxone, Sulfatide",

author = "C. Mestres and F. Reig and Busquets, {M. A.} and I. Haro and Alsina, {M. A.}",

note = "AIX{\`O} {\'E}S NOTA: ES VEU?",

year = "1991",

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doi = "10.1016/0378-5173(91)90352-O",

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T1 - Interactions of naloxone with lipid monolayers

AU - Mestres, C.

AU - Reig, F.

AU - Busquets, M. A.

AU - Haro, I.

AU - Alsina, M. A.

N1 - AIXÒ ÉS NOTA: ES VEU?

PY - 1991/9/30

Y1 - 1991/9/30

N2 - The interaction between an opioid antagonist, naloxone, and several lipids and lipid mixtures was studied using monomolecular layers as a membrane model. No specific interactions could be detected. The main factor affecting the penetration of naloxone in monolayers seems to be the initial ordered state of the molecules instead of the chemical composition of the monolayer. A new membrane model was assayed based on the retention times in high-pressure liquid chromatography working with hydrophobically modified columns.

AB - The interaction between an opioid antagonist, naloxone, and several lipids and lipid mixtures was studied using monomolecular layers as a membrane model. No specific interactions could be detected. The main factor affecting the penetration of naloxone in monolayers seems to be the initial ordered state of the molecules instead of the chemical composition of the monolayer. A new membrane model was assayed based on the retention times in high-pressure liquid chromatography working with hydrophobically modified columns.

KW - HPLC

KW - Monolayer

KW - Naloxone

KW - Sulfatide

UR - http://www.scopus.com/inward/record.url?scp=0026047737&partnerID=8YFLogxK

U2 - 10.1016/0378-5173(91)90352-O

DO - 10.1016/0378-5173(91)90352-O

M3 - Article

AN - SCOPUS:0026047737

SN - 0378-5173

VL - 76

SP - 145

EP - 149

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Interactions of naloxone with lipid monolayers

Abstract

Keywords

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