Interaction of opioid molecules with PS, PC and PS/PC monolayers

M. A. Alsina; C. Mestres; G. Valencia; J. M.García Antón; F. Reig

doi:10.1007/BF01417867

Interaction of opioid molecules with PS, PC and PS/PC monolayers

M. A. Alsina^*
, C. Mestres
, G. Valencia
, J. M.García Antón
, F. Reig

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

4 Citations (Scopus)

Abstract

The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.

Original language	English
Pages (from-to)	832-835
Number of pages	4
Journal	Colloid and Polymer Science
Volume	266
Issue number	9
DOIs	https://doi.org/10.1007/BF01417867
Publication status	Published - Sept 1988
Externally published	Yes

Keywords

Opiates
monolayers
penetration kinetics
phosphatidylcholine
phosphatidylserine

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10.1007/BF01417867

Cite this

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abstract = "The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.",

keywords = "Opiates, monolayers, penetration kinetics, phosphatidylcholine, phosphatidylserine",

author = "Alsina, \{M. A.\} and C. Mestres and G. Valencia and Ant{\'o}n, \{J. M.Garc{\'i}a\} and F. Reig",

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AU - Alsina, M. A.

AU - Mestres, C.

AU - Valencia, G.

AU - Antón, J. M.García

AU - Reig, F.

PY - 1988/9

Y1 - 1988/9

N2 - The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.

AB - The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.

KW - Opiates

KW - monolayers

KW - penetration kinetics

KW - phosphatidylcholine

KW - phosphatidylserine

UR - https://www.scopus.com/pages/publications/0024068938

U2 - 10.1007/BF01417867

DO - 10.1007/BF01417867

M3 - Article

AN - SCOPUS:0024068938

SN - 0303-402X

VL - 266

SP - 832

EP - 835

JO - Colloid and Polymer Science

JF - Colloid and Polymer Science

IS - 9

ER -

Interaction of opioid molecules with PS, PC and PS/PC monolayers

Abstract

Keywords

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