Interaction of opioid molecules with PS, PC and PS/PC monolayers

M. A. Alsina, C. Mestres, G. Valencia, J. M.García Antón, F. Reig

Research output: Indexed journal article Articlepeer-review

4 Citations (Scopus)

Abstract

The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.

Original languageEnglish
Pages (from-to)832-835
Number of pages4
JournalColloid and Polymer Science
Volume266
Issue number9
DOIs
Publication statusPublished - Sept 1988
Externally publishedYes

Keywords

  • Opiates
  • monolayers
  • penetration kinetics
  • phosphatidylcholine
  • phosphatidylserine

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