Abstract
The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compression isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.
Original language | English |
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Pages (from-to) | 832-835 |
Number of pages | 4 |
Journal | Colloid and Polymer Science |
Volume | 266 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sept 1988 |
Externally published | Yes |
Keywords
- Opiates
- monolayers
- penetration kinetics
- phosphatidylcholine
- phosphatidylserine