Improving the performance of J-modulated ADEQUATE experiments through homonuclear decoupling and non-uniform sampling

Homonuclear C-13-C-13 couplings at natural abundance can be measured using the J-modulated Adequate DoublE QUAntumTransfer Experiment (ADEQUATE) experiment. To somewhat ameliorate F-1 digitization requirements, a scaling factor was incorporated into the original pulse sequence. Non-uniform sampling provides an obvious avenue to further facilitate the acquisition of (1)J(CC) and (n)J(CC) homonuclear coupling constant data. We introduce homonuclear decoupling (HD) analogous to that described for the 1,1-HD-ADEQUATE and 1,n-HD-ADEQUATE experiments and evaluate the combination of non-uniform sampling and HD on the acquisition of both (1)J(CC) and (n)J(CC) homonuclear C-13-C-13 coupling constants using ibuprofen as a model compound. Copyright (c) 2015 John Wiley & Sons, Ltd.