Importance of receptor-targeted systems in the battle against atherosclerosis

Elisabet Rosas; Igor Sobenin; Alexander Orekhov; Elazer R. Edelman; Mercedes Balcells

doi:10.2174/1381612811319330010

Importance of receptor-targeted systems in the battle against atherosclerosis

Elisabet Rosas, Igor Sobenin, Alexander Orekhov, Elazer R. Edelman, Mercedes Balcells^*

^*Corresponding author for this work

IQS School of Engineering

Research output: Indexed journal article › Review › peer-review

6 Citations (Scopus)

Abstract

Atherosclerosis is the leading cause of death in the Western World and has been for decades a field of intense research. Yet, while there is a rich and diverse literature describing in detail the players and mechanisms involved in this complex disease in cell and animal models, we remain today with virtually no reliable markers for early diagnosis and targeted treatments options. This review is centered upon the latter. We summarize the latest studies focused on detecting endothelial dysfunction during the early stages of atherosclerosis, when the disease is asymptomatic and describe strategies recently proposed to image and target advanced plaque.

Original language	English
Pages (from-to)	5897-5903
Number of pages	7
Journal	Current Pharmaceutical Design
Volume	19
Issue number	33
DOIs	https://doi.org/10.2174/1381612811319330010
Publication status	Published - Oct 2013

Keywords

Atherosclerosis
Biomarkers
Direct targeting
Early diagnosis
Endothelial cells
Receptors

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10.2174/1381612811319330010

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title = "Importance of receptor-targeted systems in the battle against atherosclerosis",

abstract = "Atherosclerosis is the leading cause of death in the Western World and has been for decades a field of intense research. Yet, while there is a rich and diverse literature describing in detail the players and mechanisms involved in this complex disease in cell and animal models, we remain today with virtually no reliable markers for early diagnosis and targeted treatments options. This review is centered upon the latter. We summarize the latest studies focused on detecting endothelial dysfunction during the early stages of atherosclerosis, when the disease is asymptomatic and describe strategies recently proposed to image and target advanced plaque.",

keywords = "Atherosclerosis, Biomarkers, Direct targeting, Early diagnosis, Endothelial cells, Receptors",

author = "Elisabet Rosas and Igor Sobenin and Alexander Orekhov and Edelman, {Elazer R.} and Mercedes Balcells",

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AU - Rosas, Elisabet

AU - Sobenin, Igor

AU - Orekhov, Alexander

AU - Edelman, Elazer R.

AU - Balcells, Mercedes

PY - 2013/10

Y1 - 2013/10

N2 - Atherosclerosis is the leading cause of death in the Western World and has been for decades a field of intense research. Yet, while there is a rich and diverse literature describing in detail the players and mechanisms involved in this complex disease in cell and animal models, we remain today with virtually no reliable markers for early diagnosis and targeted treatments options. This review is centered upon the latter. We summarize the latest studies focused on detecting endothelial dysfunction during the early stages of atherosclerosis, when the disease is asymptomatic and describe strategies recently proposed to image and target advanced plaque.

AB - Atherosclerosis is the leading cause of death in the Western World and has been for decades a field of intense research. Yet, while there is a rich and diverse literature describing in detail the players and mechanisms involved in this complex disease in cell and animal models, we remain today with virtually no reliable markers for early diagnosis and targeted treatments options. This review is centered upon the latter. We summarize the latest studies focused on detecting endothelial dysfunction during the early stages of atherosclerosis, when the disease is asymptomatic and describe strategies recently proposed to image and target advanced plaque.

KW - Atherosclerosis

KW - Biomarkers

KW - Direct targeting

KW - Early diagnosis

KW - Endothelial cells

KW - Receptors

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JO - Current Pharmaceutical Design

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ER -

Importance of receptor-targeted systems in the battle against atherosclerosis

Abstract

Keywords

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