Abstract
An NMR method to enhance the sensitivity and resolution in band-selective long-range heteronuclear correlation spectra is proposed. The excellent in-phase nature of the selHSQMBC experiment allows that homonuclear and/or heteronuclear decoupling can be achieved in the detected dimension of a 2D multiple-bond correlation map, obtaining simplified cross-peaks without their characteristic fine J multiplet structure. The experimental result is a resolution improvement while the highest sensitivity is also achieved. Specifically, it is shown that the 1H-homodecoupled band-selective (HOBS) HSQMBC experiment represents a new way to measure heteronuclear coupling constants from the simplified in-phase doublets generated along the detected dimension.
Original language | English |
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Pages (from-to) | 63-69 |
Number of pages | 7 |
Journal | Journal of Magnetic Resonance |
Volume | 238 |
DOIs | |
Publication status | Published - Jan 2014 |
Externally published | Yes |
Keywords
- Band-selective HSQMBC
- Homonuclear decoupling
- Proton-carbon coupling constants
- Pure-shift
- Resolution enhancement
- Sensitivity improvement