Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain

Jordi Duran, Isabel Saez, Agnès Gruart, Joan J. Guinovart, José M. Delgado-García

Research output: Indexed journal article Articlepeer-review

118 Citations (Scopus)

Abstract

Glycogen is the only carbohydrate reserve of the brain, but its overall contribution to brain functions remains unclear. Although it has traditionally been considered as an emergency energetic reservoir, increasing evidence points to a role of glycogen in the normal activity of the brain. To address this long-standing question, we generated a brain-specific Glycogen Synthase knockout (GYS1Nestin-KO) mouse and studied the functional consequences of the lack of glycogen in the brain under alert behaving conditions. These animals showed a significant deficiency in the acquisition of an associative learning task and in the concomitant activity-dependent changes in hippocampal synaptic strength. Long-term potentiation (LTP) evoked in the hippocampal CA3-CA1 synapse was also decreased in behaving GYS1Nestin-KO mice. These results unequivocally show a key role of brain glycogen in the proper acquisition of new motor and cognitive abilities and in the underlying changes in synaptic strength.

Original languageEnglish
Pages (from-to)550-556
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

Keywords

  • brain glycogen
  • hippocampus
  • long-term potentiation
  • mice
  • operant conditioning

Fingerprint

Dive into the research topics of 'Impairment in long-term memory formation and learning-dependent synaptic plasticity in mice lacking glycogen synthase in the brain'. Together they form a unique fingerprint.

Cite this