TY - JOUR
T1 - Impact of obesity and Down syndrome on peak heart rate and aerobic capacity in youth and adults
AU - Wee, Sang Ouk
AU - Pitetti, Kenneth H.
AU - Goulopoulou, Styliani
AU - Collier, Scott R.
AU - Guerra, Myriam
AU - Baynard, Tracy
N1 - Funding Information:
The authors wish to thank the participants and staff who contributed to this study. Additionally, we would like to extend our appreciation to Dr. Bo Fernhall for his helpful comments on this manuscript. Tracy Baynard, Ken Pitetti, Styliani Goulopoulou, Scott R. Collier and Myriam Guerra performed the data collection. Sang Ouk Wee and Tracy Baynard developed the research question and analyzed data. All authors were involved in writing the paper and had final approval of the submitted and published versions. The study was supported in part by grants from the American Heart Association and from the National Institute on Disability and Rehabilitation Research ( H133G040323 ).
Publisher Copyright:
© 2014.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Individuals with Down syndrome (DS) exhibit reduced aerobic capacity with reduced peak heart rate (HRpeak). This condition is often coexistent with higher level of obesity compared to individuals without DS. The purpose of this study is to investigate the effects of obesity and Down syndrome (DS) on peak heart rate (HRpeak) and peak oxygen consumption (VO2peak) in children and adults both with and without intellectual disabilities (ID)s. VO2peak and HRpeak from individualized treadmill tests on 654 individuals were analyzed. Body mass index was used to categorize individuals' weight status using standard cut-offs. DS groups had the lowest HRpeak (167bpm±14, p<0.05) compared to individuals with (183bpm±12) without ID (187bpm±12). Obesity did not affect HRpeak among adults and children with DS. VO2peak was lower among individuals with DS (25.2mL/kg/min±6.3, p<0.05) when compared individuals with (37.0mL/kg/min±10.5) and without ID (36.1mL/kg/min±10.4). Obese adults with DS had lower VO2peak (24.3mL/kg/min±6.9, p=0.001) compared to the normal weight (26.7±7.1mL/kg/min) and overweight groups (27.0mL/kg/min±6.1) with DS. Conversely, in children, obesity level did not impact VO2peak in individuals with DS. Our results suggest that DS attenuates both VO2peak and HRpeak, regardless of obesity status and age group. However, obesity was associated with lower VO2peak in all adults, but not in children with DS.
AB - Individuals with Down syndrome (DS) exhibit reduced aerobic capacity with reduced peak heart rate (HRpeak). This condition is often coexistent with higher level of obesity compared to individuals without DS. The purpose of this study is to investigate the effects of obesity and Down syndrome (DS) on peak heart rate (HRpeak) and peak oxygen consumption (VO2peak) in children and adults both with and without intellectual disabilities (ID)s. VO2peak and HRpeak from individualized treadmill tests on 654 individuals were analyzed. Body mass index was used to categorize individuals' weight status using standard cut-offs. DS groups had the lowest HRpeak (167bpm±14, p<0.05) compared to individuals with (183bpm±12) without ID (187bpm±12). Obesity did not affect HRpeak among adults and children with DS. VO2peak was lower among individuals with DS (25.2mL/kg/min±6.3, p<0.05) when compared individuals with (37.0mL/kg/min±10.5) and without ID (36.1mL/kg/min±10.4). Obese adults with DS had lower VO2peak (24.3mL/kg/min±6.9, p=0.001) compared to the normal weight (26.7±7.1mL/kg/min) and overweight groups (27.0mL/kg/min±6.1) with DS. Conversely, in children, obesity level did not impact VO2peak in individuals with DS. Our results suggest that DS attenuates both VO2peak and HRpeak, regardless of obesity status and age group. However, obesity was associated with lower VO2peak in all adults, but not in children with DS.
KW - Down syndrome
KW - Obesity
KW - Peak heart rate
KW - Peak oxygen consumption
UR - http://www.scopus.com/inward/record.url?scp=84908518668&partnerID=8YFLogxK
U2 - 10.1016/j.ridd.2014.10.002
DO - 10.1016/j.ridd.2014.10.002
M3 - Article
AN - SCOPUS:84908518668
SN - 0891-4222
VL - 36
SP - 198
EP - 206
JO - Research in Developmental Disabilities
JF - Research in Developmental Disabilities
ER -
