Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children

Emilia Sánchez Ruiz, Clàudia Fortuny, Antoni Noguera-Julián, Laia Alsina, Rocío Bellido, Carmen Muñoz-Almagro, Lidia Ruiz

Research output: Indexed journal article Articlepeer-review

Abstract

The interferon-gamma release assays have greater specificity than the tuberculin skin test (TST), and at least equal sensitivity. We analyzed the sensitivity and specificity of the TST in immunocompetent children considering QuantiFERON as the referent standard. A TST cut-off
point of 5 mm indicates excellent sensitivity (100%) and specificity (93%) in children without Bacillus Calmette-Gue´rin. In Bacillus CalmetteGue´rin-vaccinated children, the TST cut-off point of 10 mm had poorer specificity (86%), and a cut-off point of 15 mm resulted in reduced sensitivity (60%).
Original languageEnglish
Pages (from-to)426-428
Number of pages3
JournalPediatric Infectious Disease Journal
Volume30
Issue number5
Publication statusPublished - 1 May 2011

Keywords

  • Tuberculosis
  • Sensitivity
  • Tuberculin skin test
  • Interferon-gamma release assays

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