Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children

Emilia Sánchez Ruiz; Clàudia Fortuny; Antoni  Noguera-Julián; Laia Alsina; Rocío Bellido; Carmen Muñoz-Almagro; Lidia Ruiz

Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children

Emilia Sánchez Ruiz, Clàudia Fortuny, Antoni Noguera-Julián, Laia Alsina, Rocío Bellido, Carmen Muñoz-Almagro, Lidia Ruiz

Blanquerna School of Health Sciences

Research output: Indexed journal article › Article › peer-review

Abstract

The interferon-gamma release assays have greater specificity than the tuberculin skin test (TST), and at least equal sensitivity. We analyzed the sensitivity and specificity of the TST in immunocompetent children considering QuantiFERON as the referent standard. A TST cut-off
point of 5 mm indicates excellent sensitivity (100%) and specificity (93%) in children without Bacillus Calmette-Gue´rin. In Bacillus CalmetteGue´rin-vaccinated children, the TST cut-off point of 10 mm had poorer specificity (86%), and a cut-off point of 15 mm resulted in reduced sensitivity (60%).

Original language	English
Pages (from-to)	426-428
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	30
Issue number	5
Publication status	Published - 1 May 2011

Keywords

Tuberculosis
Sensitivity
Tuberculin skin test
Interferon-gamma release assays

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Sánchez Ruiz, E., Fortuny, C., Noguera-Julián, A., Alsina, L., Bellido, R., Muñoz-Almagro, C., & Ruiz, L. (2011). Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children. Pediatric Infectious Disease Journal, 30(5), 426-428. https://journals.lww.com/pidj/Fulltext/2011/05000/IMPACT_OF_CD4_T_CELL_COUNT_ON_THE_OUTCOME_OF.21.aspx

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abstract = "The interferon-gamma release assays have greater specificity than the tuberculin skin test (TST), and at least equal sensitivity. We analyzed the sensitivity and specificity of the TST in immunocompetent children considering QuantiFERON as the referent standard. A TST cut-offpoint of 5 mm indicates excellent sensitivity (100%) and specificity (93%) in children without Bacillus Calmette-Gue´rin. In Bacillus CalmetteGue´rin-vaccinated children, the TST cut-off point of 10 mm had poorer specificity (86%), and a cut-off point of 15 mm resulted in reduced sensitivity (60%).",

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author = "{S{\'a}nchez Ruiz}, Emilia and Cl{\`a}udia Fortuny and Antoni Noguera-Juli{\'a}n and Laia Alsina and Roc{\'i}o Bellido and Carmen Mu{\~n}oz-Almagro and Lidia Ruiz",

note = "Fortuny C; Noguera A; Alsina L; Bellido R; S{\'a}nchez E; Mu{\~n}oz-Almagro C; Ruiz L; Jim{\'e}nez R. Supported by Fondo de Investigaci{\'o}n Sanitaria (FIS 99/0051-01). Supported by Pedro Pons Grant, Universitat de Barcelona (to L.A.).",

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language = "English",

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Sánchez Ruiz, E, Fortuny, C, Noguera-Julián, A, Alsina, L, Bellido, R, Muñoz-Almagro, C & Ruiz, L 2011, 'Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children', Pediatric Infectious Disease Journal, vol. 30, no. 5, pp. 426-428. <https://journals.lww.com/pidj/Fulltext/2011/05000/IMPACT_OF_CD4_T_CELL_COUNT_ON_THE_OUTCOME_OF.21.aspx>

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AU - Fortuny, Clàudia

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AU - Alsina, Laia

AU - Bellido, Rocío

AU - Muñoz-Almagro, Carmen

AU - Ruiz, Lidia

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Impact of CD4 t cell count on the outcome of planned treatment interruptions in early-treated HIV infected children

Abstract

Keywords

UN SDGs

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