Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery

P. Garg; S. Pandey; Hoon Seonwoo; Seungmin Yeom; Yun Hoon Choung; Chong Su Cho; Pill Hoon Choung; Jong Hoon Chung

doi:10.1039/c4cc09871d

Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery

P. Garg
, S. Pandey
, Hoon Seonwoo
, Seungmin Yeom
, Yun Hoon Choung
, Chong Su Cho
, Pill Hoon Choung^*
, Jong Hoon Chung

^*Corresponding author for this work

Research output: Indexed journal article › Article › peer-review

19 Citations (Scopus)

Abstract

Here, we introduce a polydixylitol based highly osmotic polymer that not only transmigrates the BBB by intra-arterial infusion of osmotic polyol but also triggers cellular uptake via modulation of caveolae mediated endocytosis.

Original language	English
Pages (from-to)	3645-3648
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	17
DOIs	https://doi.org/10.1039/c4cc09871d
Publication status	Published - 28 Feb 2015
Externally published	Yes

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AU - Choung, Yun Hoon

AU - Cho, Chong Su

AU - Choung, Pill Hoon

AU - Hoon Chung, Jong

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Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery

Abstract

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