Homodecoupled 1,1-and 1, n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine

Josep Sauri; Wolfgang Bermel; Alexei V. Buevich; Edward C. Sherer; Leo A. Joyce; Maged H. M. Sharaf; Paul L. Schiff; Teodor Parella; R. Thomas Williamson; Gary E. Martin

doi:10.1002/anie.201502540

Homodecoupled 1,1-and 1, n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine

Josep Sauri, Wolfgang Bermel, Alexei V. Buevich, Edward C. Sherer, Leo A. Joyce, Maged H. M. Sharaf, Paul L. Schiff, Teodor Parella, R. Thomas Williamson, Gary E. Martin

Research output: Indexed journal article › Article › peer-review

51 Citations (Scopus)

Abstract

Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1, n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.

Original language	English
Pages (from-to)	10160-10164
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	35
DOIs	https://doi.org/10.1002/anie.201502540
Publication status	Published - 24 Aug 2015
Externally published	Yes

Keywords

DFT calculations
Hd-adequate
NMR spectroscopy
Cryptolepis alkaloids
Homodecoupling

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10.1002/anie.201502540

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abstract = "Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1, n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.",

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AU - Buevich, Alexei V.

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AU - Joyce, Leo A.

AU - Sharaf, Maged H. M.

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AU - Parella, Teodor

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AU - Martin, Gary E.

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KW - Cryptolepis alkaloids

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Homodecoupled 1,1-and 1, n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine

Abstract

Keywords

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