Ground- and excited-state interactions of2,7,12,17-tetraphenylporphycene with model target biomolecules for type-I photodynamic therapy

Noemí Rubio, Víctor Martínez-Junza, Jordi Estruga, José I. Borrell, Margarita Mora, M. Lluïsa Sagristá, Santi Nonell

Research output: Indexed journal article Articlepeer-review

7 Citations (Scopus)

Abstract

Biosubstrate-sensitizer binding is one of the factors that enhances the type-I mechanism over the type-II in the whole photodynamic process. 2,7,12,17-Tetraphenylporphycene (TPPo), a second-generation photosensitizer, is a hydrophobic compound with good photophysical properties for photodynamic therapy applications that has proved its ability for the photoinactivation of different cell lines. Nevertheless, little is known about its mechanism of action. This paper focuses on the study of the interaction/binding of TPPo with different model biomolecules that may favor the type-I mechanism in the overall photodynamic process, including nucleosides, proteins, and phospholipids. Compared with more hydrophilic photosensitizers, it is concluded that TPPo is more likely to undergo type-II (singlet oxygen) than type-I (electron transfer) photodynamic processes in biological environments.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalJournal of Porphyrins and Phthalocyanines
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Gramicidin
  • Guanosine
  • Human serum albumin
  • Lipid A
  • Nucleosides
  • Phospholipids
  • Photodynamic therapy
  • Porphycenes
  • Singlet oxygen
  • Type-I mechanism

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